Most Read Articles
20 May 2019

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.
Jairia Dela Cruz, 10 Jun 2019
Statins appear to exert neuroprotective effects in diabetic prostate cancer patients receiving androgen deprivation therapy (ADT), with a recent study showing that the drug confers benefit for the risk of dementia. The benefit is greater with higher statin adherence and intensity.

Adalimumab feasible for long-term control of hidradenitis suppurativa

22 Dec 2018

Continuous weekly administration of adalimumab (ADA) at 40 mg appears to be an adequate option for long-term control of moderate-to-severe hidradenitis suppurativa (HS), a recent study has shown.

Eighty-eight study participants were given ADA (median age 35.5 years; 63.6 percent female) of whom 63 either achieved HS clinical response (HiSCR) at week 12 or showed a 25-percent reduction in abscess and inflammatory nodule (AN) counts relative to baseline (responders plus partial responders [PRR]; median age 36.0 years; 65.1 percent female).

Results were generally persistent over time. The percentage of ADA-treated patients achieving HiSCR increased from 52.3 percent at week 12 to 62.5 percent at week 36. By week 168, this proportion was back down to 52.3 percent.

Similarly, there were improvements persistent over time in the counts of AN, draining fistula, inflammatory nodules and total fistula in both groups. The same was true for pain rating. The rate of flare was low and stable.

There was also a meaningful improvement in Dermatology Life Quality Index scores in both groups, which was maintained through week 72.

In terms of treatment safety, no adverse events of opportunistic infections were seen, except for oral candidiasis, over the mean exposure duration of 2.21 and 2.26 patient-years in the ADA-treated and PRR groups, respectively. Three serious infections were reported overall, with one case of pneumonia being probably related to the treatment.

The most common treatment-emergent adverse events included hidradenitis, headaches, upper respiratory tract infections, arthralgia, diarrhoea and dizziness, among others.

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Most Read Articles
20 May 2019

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.
Jairia Dela Cruz, 10 Jun 2019
Statins appear to exert neuroprotective effects in diabetic prostate cancer patients receiving androgen deprivation therapy (ADT), with a recent study showing that the drug confers benefit for the risk of dementia. The benefit is greater with higher statin adherence and intensity.