Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.

Acute biliary pancreatitis tied to adverse outcomes in elderly patients

18 Jul 2019

Elderly patients (65 years) hospitalized with acute biliary pancreatitis (ABP) are at increased risk of adverse clinical outcomes, a study has shown.

Effective management strategies for this demographic are needed as the ageing population increases nationally, the authors said.

Forty-one percent of the 184,763 ABP admissions comprised elderly patients. Index mortality was 1.96 percent and severe acute pancreatitis (SAP) was 21.5 percent.

Elderly patients had more endoscopic retrograde cholangiopancreatography (ERCP) examinations (27.5 percent vs 23.6 percent; p<0.001) and less frequent cholecystectomies (44.4 percent vs 58.7 percent; p<0.001). They also had greater risks of mortality and SAP as well as an age-dependent increase in risks of adverse outcomes.

Within the elderly cohort, those aged 85 years had the highest risks of SAP (odds ratio [OR], 1.3, 95 percent CI, 1.2–1.4) and mortality (OR, 2.2, 1.7–2.9). This was validated in propensity score–matched analysis, which found increased odds of mortality (OR, 2.8, 2.2–3.5) and SAP (OR, 1.2, 1.1–1.3) in the elderly patients.

This study obtained 1-year longitudinal follow-up data of inpatients from the National Readmission Database. The authors evaluated all adult inpatients (18 years old) with an index primary admission for ABP between 2011 and 2014 for the following clinical outcomes: mortality, SAP and 30-day readmission. Multivariate and one-to-one propensity score–matched analyses were performed to compare outcomes between age groups (≥65 vs <65 years).

“In the elderly, acute pancreatitis [occurs] most frequently because of gallstones,” the authors said. “[H]owever, there is a paucity of national estimates evaluating outcomes of ABP.”

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Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.