Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Activity trackers a promising way to predict gout flares

Jairia Dela Cruz
14 Oct 2020

Wearable activity trackers are feasible for collecting data on physical activity patterns that may be used to estimate gout flares, as shown in a study.

“We detected a significant difference of 841 steps in the daily step count on days where a gout flare occurred versus days where no gout flare was reported,” according to investigators.

Thirty-three out of the 44 gout patients (hyperuricaemia ≥6.8 mg/dl and ≥2 self-reported flares in the previous 6 months) enrolled met the criteria for minimal activity tracker wear time (at least 80 percent of the day) and flare reporting, with tracker data available for 60.5 percent of the total 6-month study days. Their mean age was 48.8 years, 85 percent of the patients were men, and the majority (88 percent) were on allopurinol or febuxostat.

Captured data accounted for 204 (38 percent) person-weeks with flares and 340 (62 percent) person-weeks without flares. Daily step count was significantly lower during weeks with gout flares than during non-flare periods (mean, 5,900 vs 6,972; p<0.0001). However, there was no obvious change in sleep duration during flares. [Arthritis Res Ther 2020;doi:10.1186/s13075-020-02272-2]

“This finding could reflect the greater specificity of the validated flare definition, with the expectation that those flares were more severe, and less severe flares (as were sometimes captured using the broader definition) yielded a smaller impact on step counts,” the investigators explained.

Meanwhile, the results for sleep might be attributed to one of the known reported weaknesses of wearable activity trackers in overestimating sleep duration, they added. “It is also possible that sleep duration is not the optimal metric to assess in relation to gout flares, but rather, quality and stages of sleep (eg, deep sleep, REM) could be more meaningfully affected by such flares.”

Flares are a subjective and sometimes poorly captured outcome measure in gout research, the investigators noted. Given that flares are associated with patient-reported reductions in physical activity and disturbed sleep, activity trackers may represent a passive (and effectively better) way to capture these potential surrogates for gout flares. [Health Qual Life Outcomes 2012;10:117; Rheumatology 2018;57:1925-1932]

In addition, the investigators stressed the importance of defining standards for sufficient completeness of the activity tracker data to permit valid analysis.

“We found that heart rate data alone as measured by health activity tracking devices was not an ideal measure to determine whether participants are wearing such a device. Our method of imputation of wear time to 60-min intervals captured in 1-min increments for all three data types (heart rate, step count, and sleep) yielded more robust results than using heart rate data alone,” they pointed out.

“Although many participants were highly compliant with the tracker device, there were sometimes lengthy gaps of non-wear, limiting the sensitivity of the device and suggesting the importance of more real-time monitoring of participant wear patterns during the course of future studies aimed at outcome assessment,” they added.

The investigators believe that if the ability of activity tracker devices to predict a flare is validated further, such devices could free patients from having to frequently answer questions and provide patient-reported outcome data or reduce data collection burden often encountered in studies.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).