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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
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Active vitamin D linked to better gut health in elderly men

26 Dec 2020

Men who have higher serum concentration of the active form of vitamin D (1,25[OH]2D) tend to have gut flora enriched in butyrate-producing bacteria, a recent study has found. In turn, this microbiota structure may promote better gut health.

A total of 567 older men (mean age, 84.2±4.1 years) participated in a cross-sectional analysis. Serum levels of vitamin D metabolites (25-hydroxyvitamin D [25(OH)D], 1,25[OH]2D, and 24,25[OH]2D) and were measured using liquid chromatography with tandem mass spectrometry. Microbiome analysis was performed on stool samples that were subjected to 16S ribosomal RNA sequencing and taxonomic assignments.

Most (74.8 percent) of the men were taking some form of vitamin D supplementation, while only 7.2 percent were deficient. Those who were recruited from the site with the highest annual sun exposure had the highest 25(OH)D levels, but were not significantly advantaged in terms of 1,25(OH)2D, suggesting that sunlight strongly affected vitamin D stores, but not its active form.

Random forest analysis found six sub-operational taxonomic units (sOTUs) that were statistically correlated with vitamin D concentrations. In particular, 1,25(OH)2D levels correlated with the enrichment of six bacterial taxa, all under the Firmicutes phylum, Clostridia class, and Clostridia order. Notably, all taxa were recognized as producers of butyrate.

Moreover, multivariate analysis found that higher 1,25(OH)2D levels correlated significantly with greater α-diversity (p=7.23×10-7). Active vitamin D also explained the greatest proportion of variation in microbial β-diversity.

“The consistency and robustness of results in finding active vitamin D metabolites associated with more favourable gut microbial diversity, including specific microbiota that are known butyrate producers, provide potential targets for intervention, whether through dietary modification and/or vitamin D supplementation in clinically appropriate populations,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
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