Most Read Articles
Pearl Toh, 4 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 6 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Active gingival inflammation tied to hypertension

15 Oct 2020

Gingival bleeding appears to influence the association between periodontal diseases and blood pressure (BP), a study has shown. However, the burden represented by periodontitis is still vital. Periodontal assessment may be essential in difficult to control hypertension.

The authors applied survey-based propensity-score matching (PSM) that included major confounders shared between hypertension and periodontal diseases to cross-sectional NHANES III data from 5,396 adults aged 30 years who underwent BP measurement and periodontal examination. Two matched groups with and without gingival bleeding were identified.

Generalized additive models incorporating inflammatory markers were fitted to examine the association of bleeding gums with systolic (S)BP and high/uncontrolled BP. Stratification by periodontal status (healthy, gingivitis, stable periodontitis, or unstable periodontitis) was conducted. Machine learning was used to estimate variable importance.

Compared with no bleeding (healthy periodontium, stable periodontitis), gingival bleeding (gingivitis, unstable periodontitis) independently correlated with 2.6-mm Hg higher SBP (p<0.001) and with an increased risk of high/uncontrolled BP (odds ratio [OR], 1.42, 95 percent confidence interval [CI], 1.19–1.68; p<0.001). SBP was also higher among participants with unstable periodontitis than those with stable periodontitis (2.1 mm Hg; p<0.001) or gingivitis (5.3 mm Hg; p<0.001).

Moreover, unstable periodontitis (OR, 1.65, 95 percent CI, 2.14–1.82) and gingivitis (OR, 1.49, 95 percent CI, 1.22–1.82) showed a consistent relationship with an increased risk of high/uncontrolled BP. Notably, inflammatory markers conferred a maximum of 12-percent gain in the predictive power of the model.

“Cardiovascular diseases, including hypertension, are characterized by underlying systemic inflammation,” the authors said. “Periodontitis, which can impact the systemic inflammatory burden, has recently been linked to high BP.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 4 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 6 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.