Actinic keratosis risk greater in taller people
There appears to be a significant and positive correlation between height and actinic keratosis (AK), according to a recent South Korea study.
The study included 17,386,083 participants who were divided into five groups according to height. A total of 49,287 AK cases were reported, yielding an incidence rate of 0.314 per 1,000 person-years. AK was most common in participants above the age of 60 years.
Multivariate analysis showed that AK was significantly associated with height. Compared with those in the first quintile, the incidence rate of AK was higher in participants who were in the highest quintile of height (0.32755 vs 0.29771 per 1,000 person-years), as was the likelihood of AK (hazard ratio [HR], 1.284; 95 percent CI, 1.242–1.326).
The risk of AK was likewise significantly higher in participants who were in the second (HR, 1.073; 1.04–1.07), third (HR, 1.193; 1.158–1.23) and fourth (HR, 1.207; 1.169–1.246) quintiles of height. The associations were significant even after adjusting for demographic and socioeconomic factors, alcohol consumption, smoking status, and comorbidities.
In subgroup analyses, the correlation between height and AK risk was more pronounced in males (Q5 vs Q1: HR, 1.375; 1.306–1.447) than in females (Q5 vs Q1: HR, 1.237; 1.184–1.291) and in those at least (Q5 vs Q1: HR, 1.341; 1.285–1.4) vs younger (Q5 vs Q1: HR, 1.222; 1.161–1.286) than 65 years of age.