Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.

Acitretin, apremilast, methotrexate safe, effective for ICI-mediated psoriasis

30 Apr 2021

Apremilast, acitretin, and methotrexate demonstrate safety and efficacy for immune checkpoint inhibitor (ICI)-mediated psoriasis, as shown in a study, noting that ICI can be completed unhindered in most cases. In addition, a therapeutic algorithm is suggested by the investigators.

This study reported data on ICI-mediated psoriasis, emerging from the largest cohort to date, and proposed a step-by-step management algorithm. The investigators retrospectively reviewed the medical records of all patients with ICI-mediated psoriasis across nine institutions.

Of the 115 individuals included, 10 had missing data. Grade 1, 2, and 3 disease severity was reported in 60 (57.1 percent), 34 (32.4 percent), and 11 (10.5 percent) of 105 participants, respectively. The ratio between exacerbation and de novo cases was 1:4:3.

Acitretin was the most common systemic therapy (n=23; 20.1 percent), followed by systemic steroids (n=8; 7 percent), apremilast (n=7; 6.1 percent), methotrexate (n=5; 4.3 percent), and biologic agents (n=4; 3.6 percent). Moreover, 29 of 112 patients (25.9 percent) interrupted and 20 of 111 (18 percent) permanently discontinued ICIs due to psoriasis.

Notably, body surface area of >10 percent at baseline was associated with a higher likelihood for ICI treatment modification (odds ratio [OR], 3.64, 95 percent confidence interval [CI], 1.27–10.45; p=0.03) and greater risk for permanent discontinuation (OR, 6.41, 95 percent CI, 2.40–17.11; p<0.001).

Additionally, guttate psoriasis and grade 2 or 3 disease were found to be significant positive predictors for antitumour response of ICI; pruritus, on the other hand, was a negative predictor.

This study was limited by its retrospective design, according to the investigators.

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.