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Tristan Manalac, 5 days ago
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Acetaminophen safe for seniors in nursing homes

12 Apr 2019
Acetaminophen affects brain's response when people commit errors.

Acetaminophen remains a safe choice of analgesic for most elderly residents of nursing homes, a recent study suggests.

Researchers prospectively analysed 5,429 elderly adults (mean age, 86.1±8.1 years; 73.9 percent female) living across 175 nursing homes. Baseline prescriptions were assessed for acetaminophen use, either alone or in combination with other medications. The primary study outcome was 18-month mortality, while myocardial infarction (MI) and stroke events were secondary outcomes.

Less than half (41.2 percent; n=2,239) of the participants were on acetaminophen medication and were included in the analysis of the primary outcome. Those with a history of stroke (n=628) and MI (n=243) and those who had died (n=1,629) were excluded for the analysis of the secondary outcomes.

There were 667 deaths in the acetaminophen group and 940 in those not on the medication. The resulting incident mortality rates were comparable between the two groups (22.34 vs 22.16 per 100 person-years; p=0.8809).

Propensity score matching did not meaningfully alter the findings. The resulting incident mortality rates in the acetaminophen and no-acetaminophen groups were 21.56 and 22.88 percent person-years, respectively, which yielded a nonsignificant difference (p=0.3283).

Similar findings were obtained for the secondary outcomes. The incidence rates of MI were 2.31 percent and 2.04 percent in those who were and were not on acetaminophen medication (p=0.5890). Stroke incidence was likewise comparable between the two groups (4.64 percent vs 3.85 percent; p=0.2765).

Logistic regression analysis further proved no significant link between acetaminophen use and death (hazard ratio, 0.97; 95 percent CI, 0.86–1.10; p=0.64), MI (odds ratio [OR], 1.37; 0.75–2.53; p=0.31) and stroke (OR, 1.13; 0.74–1.72; p=0.59).

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Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.