Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Accounting for risk may improve treatment outcomes in kids with ALL

16 Mar 2020
Trojan Horse for cancer cells

Risk stratification and risk-guided therapy improves event-free survival (EFS) in children with acute lymphoblastic leukaemia (ALL), a recent study has found.

The study included 1,138 children with non-T-cell ALL who were stratified into three groups according to age, white blood cell count, genetic profile and treatment response: standard risk (SR; n=456), high risk (HR; n=543) and extremely high risk (ER; n=139). Study outcomes included 4-year EFS and overall survival (OS).

Almost all the participants achieved complete remission (96.4 percent); only 38 failed to reach remission, of whom two died of leukaemia-related complications. Two patients developed secondary neoplasms after allogeneic haematopoietic cell transplantation (HCT), though both were still alive at last follow-up.

The 4-year EFS and OS rates were 85.4 percent and 91.2 percent, respectively. In the intention-to-treat analysis, the risk-stratified EFS rates were 90.3 percent in SR, 84.9 percent in HR and 66.5 percent in ER. The 4-year cumulative incidences of relapse in the respective risk groups were 8.7±1.4 percent, 13.4±1.7 percent and 30.4±5.3 percent.

Risk-adjusted therapy also appeared to improve treatment outcomes, leading to a 4-year EFS rate of 90.4±1.4 percent in the SR group. In comparison, the respective rates for HR and ER patients were 84.9±1.6 percent and 66.5±4.0 percent.

“In summary, refined stratification and risk-adjusted therapy in [this population] resulted in improved EFS of SR patients. New therapeutic strategies, including molecular targeting agents, immunotherapy, and innovative cell therapy are needed to improve the outcome of HR patients,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.