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01 Aug 2016
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About half of CVD patients could be eligible for PCSK9 inhibitors

10 Jan 2018

About half of patients with cardiovascular disease (CVD) may be eligible for proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitor therapy and results from a study of a large Canadian population-based cohort show such therapy may prevent CV events, though with significant costs. [Ko DT, et al, AHA 2017, abstract 778]

Among 62,729 adult patients with CVD, 61 percent, or 2.6 percent of the general population, were eligible for PCSK9 inhibitors based on eligibility criteria of the FOURIER trial (ie, fasting LDL-cholesterol 70 mg/dL or non–HDL-cholesterol ≥100 mg/dL while on an optimized lipid-lowering regimen).

“Applying the FOURIER hazard ratio to our study, we found a reduction in primary outcome [CV death, MI, unstable angina, stroke or coronary revascularization] of about 1.3 percent with PCSK9 inhibitors, which is similar to results of the FOURIER study,” said lead researcher Dr Dennis Ko of the Institute for Clinical Evaluative Sciences in Toronto, Ontario, Canada. 

“This was associated with a high cost per event,” he added, noting that the anticipated absolute clinical benefit in their trial may be smaller than reported in other PCSK9 inhibitor trials because of low overall event rates.

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Most Read Articles
01 Aug 2016
Tigecycline is effective against Acinetobacter spp. and Stenotrophomonas maltophilia, based on the SENTRY Antimicrobial Surveillance Program.
02 Apr 2018
JARDIANCE® (Empagliflozin)
Boehringer Ingelheim (Malaysia) Sdn Bhd
    
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Pearl Toh, 6 days ago
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.