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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
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Abnormal liver function in COVID-19 tied to longer hospital stay

17 Apr 2020

Patients with coronavirus disease 2019 (COVID-19) may present with abnormal liver function, which in turn is associated with longer hospital stay, a study reports.

Researchers looked at 148 consecutive patients (mean age, 50 years; 50.68 percent male) admitted at the Shanghai Public Health Clinical Center from January 20 through 31, evaluating patient outcomes until February 19. Abnormal liver function was defined as elevation in concentrations of alanine and aspartate aminotransferase, gamma glutamyltransferase, alkaline phosphatase, and total bilirubin.

Fifty-five COVID-19 patients presented with abnormal liver function at hospital admission. Most of these patients were men and had higher levels of procalcitonin and C-reactive protein.

Significantly more patients in the abnormal liver function group had high fever than in the group with normal liver function (14.5 percent vs 4.3 percent; p=0.027). There was no between-group difference in medications taken before hospitalization, although a markedly higher proportion of patients in the former group had received lopinavir/ritonavir after admission (57.8 percent vs 31.3 percent).

Mean hospital stay was significantly longer in the group of patients with abnormal liver function than in those with normal liver function (15.09 vs 12.76 days; p=0.021).

The researchers explained that SARS-CoV-2, the causative agent for COVID-19, potentially causes liver function damage and that liver injury following admission may be associated with the use of lopinavir/ritonavir. These data may guide clinical treatment of patients during the current pandemic.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.