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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
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Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Ablative radiotherapy improves survival in patients with second NSCLC

6 days ago

Ablative radiotherapy for new primaries leads to improved overall survival (OS) compared with initial lung cancer stereotactic body radiation therapy (SBRT) in inoperable patients, a recent study has shown.

Records of inoperable patients who underwent thoracic SBRT from February 2007 to April 2019 were retrospectively reviewed. Those with previous small cell lung cancers or SBRT treatments for tumours other than nonsmall cell lung cancers (NSCLC) were not included.

The authors performed multivariate Cox regression and matched pair cohort analyses to assess the prognoses of patients undergoing definitive SBRT for a new second primary.

Overall, 438 patients with NSCLC were included, of whom 84 had previously received treatment. In univariate log-rank tests, OS was associated with gender, Karnofsky performance status (KPS), prior lung cancer, anticoagulation use, and history of heart disease (p<0.05).

These factors were then integrated into a multivariate Cox regression model. As a result, female sex (hazard ratio [HR], 0.68; p=0.004), KPS (HR, 2.0; p<0.001), and prior lung cancer (HR, 0.7; p=0.049) significantly correlated with OS. A similar approach showed that only gender (HR, 0.64; p=0.017) and tumour stage (HR, 1.7; p=0.02) were associated with relapse-free survival.

Additionally, propensity-score matching was conducted to support the Cox regression analysis using gender, age, KPS, tumour stage, history of heart disease, and anticoagulation use. On Kaplan-Meier analysis within the matched pairs, prior lung cancer was found to correlate with improved OS (p=0.011), but not with relapse-free survival (p=0.44).

“Physicians should not be dissuaded from offering SBRT to such patients,” the authors said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.