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Ablative fractional CO2 laser effective for burn scars

20 May 2019
Sunburn rashes could develop into blisters

Three treatments of ablative fractional CO2 laser (AFCO2L) yield improvements in burn scar pain, itch and dermal architecture 6 weeks after treatment, a recent study has found.

Twenty adult patients (mean age, 29 years) with burn scars were included in the study. Scar regions were randomly assigned as treatment or control zones; all scar areas received standard care. Treatment involved three standardized laser treatments 4–6 weeks apart.

After 6 weeks, there were significant improvements in pain (p=0.047) and itch (p<0.01) scores of the patient scar assessment scale (POSAS) in the treated vs control scar areas. In contrast, no significant differences were observed in any of the Vancouver Scar Scale (VSS) domains.

Polarized light microscopy was then used to measure changes in collagen. Scar zones that received AFCO2L treatment had significantly smaller yellow fibre areas in the superficial dermis compared with control zones. In comparison, both treated and untreated scar areas showed significant 6-week reductions in the area containing orange fibres in the superficial dermis.

On the other hand, the treatment had no significant effect on deep dermis tissue sections, nor did it elicit significant between-group differences in collagen orientation.

Nine patients provided data for the long-term follow-up. Total POSAS scores improved significantly in both treated and untreated zones, but no significant between-group differences were reported. The same was true for collagen measures.

“In this group of patients, AFCO2L significantly improved scar itch, pain and dermal architecture after 3 treatments. Data from initial long-term follow-up shows a trend of sustained improvement,” said researchers.

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Most Read Articles
5 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 2 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
2 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.