Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Abemaciclib + endocrine therapy may reduce recurrence risk in high-risk early breast cancer

Roshini Claire Anthony
06 Nov 2020

Adding abemaciclib to adjuvant endocrine therapy (ET) resulted in improved invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in women with hormone receptor (HR)+, HER2-negative, node-positive early breast cancer at high risk of recurrence, results of the phase III monarchE* trial showed.

“This is the first time in more than 20 years that we have seen an advance in the adjuvant treatment of this form of breast cancer,” said lead author Professor Stephen Johnston from the Royal Marsden Hospital NHS Foundation Trust, London, UK, at ESMO 2020.

“We found a 25 percent reduction in recurrence of cancer with the first 2 years when abemaciclib was added to hormone therapy compared to hormone therapy alone,” he said.

Participants in this multinational, open-label study were 5,637 adults (median age 51 years, 99.4 percent female, 56.5 percent postmenopausal at diagnosis) with HR+, HER2-negative, high-risk** early breast cancer who had completed primary treatment. Patients were randomized to receive standard-of-care (SoC) adjuvant ET alone or with abemaciclib (150 mg BID for 2 years), following which all patients received ET for 5–10 years. Patients were followed up for a median 15.5 months and received abemaciclib and ET for a median 14 and 15 months, respectively. Most patients had received radiotherapy or chemotherapy (95.4 percent in each group).

Analysis following 323 IDFS events showed that patients who received ET plus abemaciclib experienced a 25.3 percent reduced risk of IDFS vs ET alone (hazard ratio [HR], 0.75, 95 percent confidence interval [CI], 0.60–0.93; p=0.01; 2-year IDFS: 92.2 percent vs 88.7 percent). [ESMO 2020, abstract LBA5_PR; J Clin Oncol 2020;doi:10.1200/JCO.20.02514]

The results were generally consistent across prespecified subgroups. The researchers also noted a 37 percent reduced risk of IDFS with abemaciclib plus ET among premenopausal women.

ET plus abemaciclib also improved DRFS rates compared with ET alone (HR, 0.72, 95 percent CI, 0.56–0.92; pnominal=0.01; 2-year DRFS: 93.6 percent vs 90.3 percent).

Overall survival (OS) was still immature at time of analysis (deaths: 1.4 percent [abemaciclib-ET] vs 1.3 percent [ET alone]).

The most common adverse events (AEs) in abemaciclib recipients were diarrhoea, neutropenia, and fatigue, and in ET-alone recipients, arthralgia, hot flush, and fatigue.

Grade 3 AEs were more common in the abemaciclib vs ET-alone group (45.9 percent vs 12.9 percent), as were serious AEs (12.3 percent vs 7.2 percent), with pneumonia the most frequent serious AE (0.8 percent vs 0.5 percent). Venous thromboembolism and interstitial lung disease were more common in abemaciclib than ET-alone recipients.

About 68 percent of abemaciclib recipients required dose adjustments due to AEs, with 16.6 percent discontinuing the drug and 6.2 percent discontinuing abemaciclib and ET. Twenty-one ET-alone recipients discontinued treatment due to AEs. There were 14 deaths in each arm.

 

Future SoC?

“[U]p to 20 percent of patients [with HR+ HER2-negative breast cancer] may experience disease recurrence in the first 10 years, often with distant metastases, at which time the disease is incurable,” noted the researchers. Patients with high-risk clinical and/or pathologic features have a higher recurrence risk “especially during the first few years on adjuvant ET.”

“These patients with high-risk early breast cancer show a degree of resistance to hormone therapy, relapsing early despite everything we currently give them,” said Johnston.

In this study, despite >95 percent receiving chemotherapy or radiotherapy, 11.3 percent of ET-alone recipients experienced recurrence within 2 years, the researchers pointed out.

“This is the first study to show that adding a CDK4/6 inhibitor to ET significantly improves IDFS in the adjuvant setting,” said chair of the ESMO Guidelines Committee, Associate Professor Giuseppe Curigliano from the University of Milan, Italy.

“[These] findings will change practice. Once approved for high-risk HR+ HER2-negative early breast cancer, the new SoC for these patients will be to add 2 years of abemaciclib to ET,” he added.

The long-term benefits of this combination as well as the role of CDK4/6 inhibitors in preventing recurrence in patients with lower risk are yet undetermined, the researchers said. “[U]nderstanding the tumour biology of patients who benefit most from adjuvant abemaciclib is [also] important.”

“The biology of early recurrence, such as currently assessed in monarchE, may be quite different from that of late recurrence. Longer follow-up of monarchE is therefore critical to confirm the persistence of the clinical benefit now reported and the proportionality of the annual hazards for recurrence,” said Professor Antonio Wolff from The Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, Maryland, US, in an editorial. [J Clin Oncol 2020;doi:10.1200/JCO.20.02688]

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).