Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Stephen Padilla, 3 days ago
High-flow oxygen is not associated with an increase or a decrease in 30-day mortality, suggesting no benefit in most patients presenting with a suspected acute coronary syndrome (ACS), reports a New Zealand study.

Abdominal obesity ups risk of rheumatoid arthritis in women

16 Feb 2021

Abdominal obesity appears to contribute to an increased risk of rheumatoid arthritis (RA), particularly seropositive RA, among young and middle-aged women, a study has shown. However, it does not independently contribute to RA risk beyond general obesity.

The investigators followed a total of 50,682 women (1986–2014) in the Nurses’ Health Study (NHS) and 47,597 women (1993–2015) in NHS II without RA at baseline. Then, they obtained waist circumference (WC), body mass index (BMI), health outcomes, and covariate data through biennial questionnaires. Chart review was used to identify incident RA cases and serologic status.

Finally, the investigators used time-varying Cox proportional hazards models to examine the associations of WC and BMI with RA risk. They repeated analyses restricted to those aged ≤55 years.

A total of 844 incident RA cases (527 NHS and 317 NHS II) had been identified over 28 years of follow-up. Women with WC >88 cm (35 in) were at greater risk of RA (hazard ratio [HR], 1.22, 95 percent confidence interval [CI], 1.06–1.41). A similar association was seen for seropositive RA, which was more robust among young and middle-aged women. Further adjustment for BMI eased the association to null.

On the contrary, BMI correlated with RA (BMI ≥30 vs <25 kg/m2: HR, 1.33, 95 percent CI, 1.05–1.68) and seropositive RA, even after adjusting for WC. Just like in WC analyses, this association was more pronounced among young and middle-aged women.

“Being overweight or obese increases RA risk among women, particularly among those diagnosed at a younger age,” the investigators said. “Abdominal obesity may contribute to systemic inflammation more than general obesity.”

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Stephen Padilla, 3 days ago
High-flow oxygen is not associated with an increase or a decrease in 30-day mortality, suggesting no benefit in most patients presenting with a suspected acute coronary syndrome (ACS), reports a New Zealand study.