Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
29 Jun 2019
Monotherapy with a proton pump inhibitor appears to be effective in the treatment of functional dyspepsia symptoms associated with gastro-oesophageal reflux disease, according to a study.
07 Aug 2019
The combination of metformin, nystatin, linagliptin, rivaroxaban and a high-protein diet is the main cause of nasoenteral tube obstruction, with corresponding odds ratios of 2.0, 3.1, 4.3, 2.4 and 1.9, according to a recent study.

Abdominal obesity strongly predictive of advanced colorectal neoplasia in men

17 Jul 2019

Abdominal obesity, measured by waist circumference (WC), is a more robust predictor of the risk of advanced colorectal neoplasia (CRN) than overall obesity, measured by body mass index (BMI), in men, according to a study.

The authors performed a cross-sectional study on 154,552 asymptomatic examinees (mean age, 42.6 years; 65.2 percent men) who underwent colonoscopy for a health check-up to assess whether WC was associated with CRN risk, independent of BMI.

In patients in WC quartiles 1, 2, 3 and 4, the prevalence rate of CRN was 15.6 percent, 18.1 percent, 20.4 percent and 22.0 percent among men, respectively. The corresponding CRN rate among women was 7.8 percent, 9.4 percent, 12.2 percent and 15.8 percent.

WC and BMI were independently associated with overall CRN and nonadvanced CRN in both men and women. The association of BMI with advanced CRN decreased to null in men after adjusting for WC (Q2: odds ratio [OR], 0.93, 95 percent CI, 0.79–1.10; Q3: OR, 0.85, 0.71–1.03; Q4: OR, 0.99, 0.80–1.22, compared with Q1; p-trend=0.822).

On the other hand, the association of WC with advanced CRN was consistent even after adjusting for BMI (Q2: OR, 1.20, 1.02–1.42; Q3: OR, 1.45, 1.20–1.75; Q4: OR, 1.64, 1.32–2.04, compared with Q1; p-trend<0.001).

Neither WC nor BMI correlated with advanced CRN risk in women.

“Our findings suggest that abdominal obesity is more strongly predictive of advanced CRN than overall obesity in men,” the authors said, noting that previous studies have shown an association between abdominal obesity and CRN.

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Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
29 Jun 2019
Monotherapy with a proton pump inhibitor appears to be effective in the treatment of functional dyspepsia symptoms associated with gastro-oesophageal reflux disease, according to a study.
07 Aug 2019
The combination of metformin, nystatin, linagliptin, rivaroxaban and a high-protein diet is the main cause of nasoenteral tube obstruction, with corresponding odds ratios of 2.0, 3.1, 4.3, 2.4 and 1.9, according to a recent study.