Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.

Abbreviated eptifibatide bolus-only regimen noninferior to, safer than conventional approach

6 days ago
Add-on eptifibatide, infused intravenously, seems to be unnecessary for the adjunctive antithrombotic treatment during primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI), a recent study has found.

Instead, an abbreviated bolus administration of eptifibatide appears to be sufficient, providing noninferior improvements in terms of infarct size, and leading to lower rates of bleeding complications.

The study included 720 STEMI patients who were given eptifibatide treatment either through an abbreviated bolus-only (n=147; mean age, 62.4±11.3 years; 24 percent female) approach or conventionally, where an infusion followed the bolus administration (mean age, 60.5±10.5 years; 19 percent female). Outcomes included infarct size and major bleeding.

Myocardial infarct size, assessed through peak myocardial bound creatine kinase (CK-MB) values, was comparable in the abbreviated- and conventional-treatment arms (204±149 vs 238±173 IU/L; relative difference, –8.4 percent, 95 percent confidence interval [CI], –31.2 to 14.4). The same was true for peak CK values.

In particular, the upper limits of both peak CK-MB and CK did not breach the 20-percent prespecified noninferiority margin, indicating that the bolus-only approach was indeed noninferior to the conventional treatment regimen.

Resolution of ST-segment in electrocardiography also occurred comparably between groups (relative difference, 3.6 percent, 95 percent CI, –5.5 to 12.8).

On the other hand, major bleeding complications occurred at a significantly lower frequency in patients receiving the abbreviated treatment (32 percent vs 47 percent; p=0.01), corresponding to a 52-percent drop in the risk of such complications (odds ratio, 0.48, 95 percent CI, 0.29–0.79).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.