Most Read Articles
Stephen Padilla, 14 Aug 2019
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
4 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
2 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.

6-week varenicline preloading cuts smoke rates, prolongs abstinence

Stephen Padilla
06 Jun 2019
Prof Gabriel Izbicki, MD

Extended preloading of varenicline for 6 weeks before the target quit day (TQD) safely improves the efficacy of the prescription medication in facilitating smoking cessation at 12 weeks and at 6 months, according to a study presented at the American Thoracic Society (ATS) 2019 International Conference, held at Dallas, Texas in the US.

This randomized, double-blind, placebo-controlled trial involved an 18-week treatment period and 12-week follow-up to determine the efficacy and safety of 6-week varenicline preloading in supporting smoking reduction and increasing smoking abstinence at 24 weeks after randomization.

A total of 242 adults motivated to quit were randomly assigned (1:1) to receive either varenicline preloading for 6 weeks prior to the TQD (extended preloading group [EPG]) or placebo for 5 weeks, followed by varenicline for 1 week before the TQD (standard preloading group [SPG]).

Biochemically validated continuous abstinence during weeks 6 through 18 and 30 was the primary outcome, while secondary ones included biochemically validated prolonged abstinence at the above time points and point prevalence abstinence at weeks 4, 6, 7, 12, 18 and 30.

Rates of continuous abstinence were significantly higher in the EPG than the SPG at weeks 18 (24.8 percent vs 7.4 percent; p<0.001) and 30 (23.1 percent vs 4.1 percent; p<0.001). Point prevalence abstinence rates were likewise significantly higher in the EPG at all time points (range, 18.2–43.8 percent vs 3.3–24.8 percent; p range: p<0.001 to p=0.003). [ATS 2019, abstract A2378]

However, adverse effects, particularly nausea (p<0.001) and vomiting (p=0.030), were significantly more frequent in the EPG at week 4. Overall, extended preloading was deemed safe, causing only mild and well tolerated symptoms.

“Extending the duration of prequit varenicline from 1 week to 6 weeks reduced smoke rates in the run-in period and enhanced the efficacy of varenicline for smoking cessation at 12 weeks and at 6 months,” said sub-investigator Prof Gabriel Izbicki, MD, from Shaare Zedek Medical Center in Jerusalem, Israel.

“Varenicline preloading appears to be a valid option for smokers willing to reduce the number of cigarettes per day (CPD), with the goal of quitting in the next weeks,” he added.

In this study, smoking abstinence referred to self-reported abstinence, validated biochemically by expired carbon monoxide (CO) readings of 5 ppm, and had to correlate with a concomitant urinary cotinine level 1 mg.mL-1 at weeks 6 and 30.

Efficient smoking reduction, on the other hand, was defined as self-reported decrease of 50 percent in the number of CPD and is usually accompanied by a decrease in expired CO and urinary cotinine.

An effective prescription medication for facilitating smoking cessation, varenicline is usually initiated 1 week before the TQD.

In an earlier study, evidence showed that 4-week use of varenicline, instead of 1 week, before the TQD could lead to substantial reduction in ad lib smoking and improve 12-week quit rates. [Arch Intern Med 2011;171:770-777]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 14 Aug 2019
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
4 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
2 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.