Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

2 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

30-day mortality rates post-TAVR halved in 10 years

Elvira Manzano
29 Oct 2019

The 30-day mortality rates among patients undergoing transcatheter aortic valve replacement (TAVR) have decreased by more than half over the last decade, with significant differences between genders,  a CENTER* collaboration analysis has shown.

Women experienced more bleeds whereas men had higher rates of permanent pacemaker use. “These findings emphasize increased safety and can reassure patients,” said lead author Dr Ronak Delewi from University of Amsterdam, the Netherlands during a presentation at TCT 2019. “The higher risk of major or life-threatening bleeds in women undergoing TAVR suggests that special care should be taken to reduce or recognize bleeding early,” he added. [Am Coll Cardiol 2019; doi: 10.1016/j.jacc.2019.09.015]

In women, bleeding risk was inversely correlated with body mass index (BMI). Patients with lower BMI had more bleeding vs those with higher BMI, a pattern that was not observed in men.

Too large a device poses bleeding risk

Dr Ayman Elbadawi from the University of Texas Medical Branch in Galveston, Texas, US said this could be due to device ‘missizing’.

“Women with lower BMI may be given a device that is too large for them, and this comes with higher risk of bleeding and vascular complications,” he said. “It’s important to identify women at high risk and spend time making sure the access is appropriate and bleeding complications are minimized.”

“This is a very helpful study because it’s giving us feedback on real-world practice in TAVR,” Elbadawi, who was unaffiliated with the study, said. The findings also highlight the importance of appropriate imaging of the iliofemoral vasculature in women. “Future studies on anatomical and procedural predictors of access-site-related major and life-threatening bleeding, specified per genders, would help reduce bleeding.”

The study included 12,381 men and women who underwent transfemoral TAVR from 2007 through 2018 and who were enrolled in global registries or prospective studies.

Women were more likely to have hypertension and an estimated glomerular filtration rate (eGFR) below 30 mL/min/m2 vs men. They were also less likely to have other traditional cardiovascular comorbidities. The risk of mortality was comparable between genders on both the logistic EuroSCORE and the EuroSCORE II. However, predicted mortality was higher in women vs men (p< 0.001) on the STS score.

Stroke rates similar, yet women more likely to die within 30 days

Stroke rates remained consistent over the years for both genders. In-hospital stroke and all-cause mortality were comparable in men and women. Similarly, at 30 days the rate of stroke was 2.3 percent in women and 2.5 percent in men (p= 0.53). All-cause death was 5.9 percent in women and 5.5 percent in men (p= 0.17).

However, the risk of a life-threatening or major bleed was significantly greater in women than in men (6.7 percent vs 4.4 percent; p< 0.001). Among patients who had a serious bleed, women were more likely than men to die within 30 days (20.1 percent vs 14.4 percent; p= 0.09).

Analyses by valve type showed that major or life-threatening bleed was higher in women than in men with both early-generation valves (6.0 percent vs 2.7 percent; p< 0.001) and newer-generation valves (4.1 percent vs 2.2 percent; p= 0.01). Regardless of the valve type, men had significantly higher rates of permanent pacemaker use. Rates of myocardial infarction and new-onset atrial fibrillation were comparable between genders.

“These data are reassuring for improvements in devices and techniques facilitating reduction in procedural complications, as well as careful patient selection avoiding TAVR in prohibitive-risk patients in whom it is futile. However, the stroke incidence is sobering, showing neither a decrease in females nor males,” Delewi said. More studies are clearly warranted to understand the lack of improvement in stroke.

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

2 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.