Most Read Articles
08 Nov 2018
Infants born through caesarean delivery appear to be at higher risk of food allergies, while those born very preterm have lower risks, a recent study has found.
04 Nov 2018
Home-based behavioural therapy, administered by parents with over-the-phone assistance with a therapist, effectively reduces complex motor stereotypies in children, a new study has found.
Jairia Dela Cruz, 15 Oct 2018
Infants treated with phototherapy are at increased risk of developing seizures in childhood, with the risk more pronounced in boys and independent of bilirubin levels, a study has found.
28 Oct 2018
Schoolchildren with severe eczema are at heightened risk of mental health problems including emotional symptoms, conduct problems, hyperactivity/inattention and peer problems, a study has found.

1-hour postload hyperglycaemia in obese children tied to unfavourable metabolic profile

07 Nov 2018

Plasma glucose levels at 1 hour (1h-GL) of ≥8.6 mmol/L during an oral glucose tolerance test (OGTT) in obese children appear to be associated with hyperinsulinaemia, insulin resistance (IR), elevated levels of interleukin (IL)-6 and visfatin, and reduced adiponectin, a study has found.

Researchers classified 88 obese children according to 1h‐GL during an OGTT: group 1 comprised those with 1h‐GL <8.6 mmol/L (n=57) while group 2 included those with 1h‐GL ≥8.6 mmol/L (n=31). Outcomes investigated included specific IR indices (HOMA‐IR, Matsuda index and Cederholm insulin sensitivity index [ISI]), lipid levels and proinflammatory biomarkers correlated with obesity complications (adiponectin, leptin, visfatin and IL‐6).

Compared with those in group 1, children in group 2 had higher insulin (median, 15.5 vs 10.9 μU/mL) and HOMA‐IR (median, 3.41 vs 2.34), as well as lower Matsuda index (median, 4.7 vs 18.4) and Cederholm ISI (38 vs 56; p<0.001 for all).

Moreover, group 2 vs 1 showed greater levels of visfatin (15.4 vs 10.1 ng/mL) and IL‐6 (12.5 vs 4.8 pg/mL), and lower adiponectin concentration (5.9 vs 11.8 μg/mL; p<0.001 for all).

Logistic regression analysis showed that the between-group differences persisted independent of age, sex, Tanner stage, body mass index and waist circumference z‐scores.

The present data indicate that 1h-GL hyperglycaemia in obese children is associated with an unfavourable overall metabolic profile that may lead to overt type 2 diabetes and cardiovascular disease later in life, researchers said. Therefore, 1h-GL>8.6 mmol/L during OGTT could be used as an additional marker to help identify those who are at increased risk of developing obesity complications.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
08 Nov 2018
Infants born through caesarean delivery appear to be at higher risk of food allergies, while those born very preterm have lower risks, a recent study has found.
04 Nov 2018
Home-based behavioural therapy, administered by parents with over-the-phone assistance with a therapist, effectively reduces complex motor stereotypies in children, a new study has found.
Jairia Dela Cruz, 15 Oct 2018
Infants treated with phototherapy are at increased risk of developing seizures in childhood, with the risk more pronounced in boys and independent of bilirubin levels, a study has found.
28 Oct 2018
Schoolchildren with severe eczema are at heightened risk of mental health problems including emotional symptoms, conduct problems, hyperactivity/inattention and peer problems, a study has found.