Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

‘Sandwich’ sequencing of adjuvant chemoradiation tied to less toxicity in advanced endometrial cancer

6 days ago

Survival and clinical outcomes in patients with advanced stage endometrial cancer are comparable among the different sequences of adjuvant chemotherapy and radiation therapy, a recent study has shown. However, “sandwich” therapy results in less chronic toxicity, which provides an opportunity for a better quality of life in survivorship.

The investigators compared outcomes and toxicities after sandwich chemoradiation (chemotherapy, then radiation, then chemotherapy) and nonsandwich sequences (chemotherapy then radiation, radiation then chemotherapy, or concurrent chemoradiation). They recorded baseline characteristics, adjuvant treatment details, clinical outcomes, and toxicities for stage III to IVA patients who underwent surgical staging followed by both adjuvant chemotherapy and radiation therapy at their institution.

Afterwards, they analysed the effects of adjuvant treatment order (sandwich or nonsandwich) on the abovementioned outcomes. Toxicities were graded according to Common Terminology Criteria for Adverse Events (CTCAE) v4.0.

A total of 107 patients were recruited, with a median follow-up of 3.2 years. Five-year local, regional, and distant recurrences were 7 percent, 15 percent, and 33 percent, while disease-free and overall survival were 61 percent and 68 percent, respectively. No difference in outcomes by sequence group was observed.

The overall rate of acute toxicity also did not differ by sequence group. Notably, patients in the sandwich group had significantly lower overall rate of chronic toxicity (p<0.001), as well as chronic genitourinary (p=0.048) and gynaecologic toxicities (p<0.001). No grade 4 or 5 acute or chronic toxicities occurred.

“Radiation is frequently added to chemotherapy for adjuvant treatment of advanced stage endometrial cancer,” the investigators said. “Multiple adjuvant therapy sequencing options exist, and little data is available to compare these.”

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).