Most commonly presents as a painless testicular mass
Occurs most often in young & middle-aged men, ie age 15-40 yr
Highly treatable disease w/ a high cure rate; survival rate in 5 yr is >95%
Testicular primary germ cell tumors (GCT) coming from the malignant transformation of primordial germ cells make up 95% of all testicular cancer; approximately 5% are extragonadal germ cell tumors (EGGCT) & are found midline in the body, eg cerebrum, mediastinum or retroperitoneum
Pathognomonic for GCT is the isochromosome of the short arm of chromosome 12 [i(12p)]
Risk factors include:
Cryptorchidism – abdominal cryptorchid testes have a higher risk than inguinal cryptorchid testes
Family history of testicular cancer in 1st-degree relatives (father or brother)
Personal history of testicular cancer
Presence of contralateral tumor or testicular intraepithelial neoplasia (TIN)
While most patients do not have such concerns, some young men treated for testicular cancer experience sexual dysfunction and other reproductive concerns 2 years after diagnosis, a recent study has found.
Coadministration of DHA and vitamin E supplements results in increased sperm motility, but no significant changes have been observed in sperm morphology and vitality in asthenozoospermic men, a study has shown.