systemic%20lupus%20erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.

Introduction

  • Predominantly diagnosed in females of childbearing age
    • Rarely diagnosed before 8 years old
  • Clinical presentation varies in different patients & the disease activity varies over time in a single patient
    • Majority of patients have arthralgia of the hand

Definition

  • Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens & immune-complex formation
    • SLE can be suspected when ≥2 organ systems are involved

Signs and Symptoms

Clinical features of systemic lupus erythematosus (SLE)

  • Cardiac
    • Endocarditis
    • Myocarditis
    • Pericarditis
  • Constitutional
    • Fatigue
    • Fever
    • Weight loss
  • Dermatological
    • Alopecia
    • Butterfly rash
    • Mucous membrane lesion
    • Photosensitivity
    • Purpura
    • Raynaud’s phenomenon
    • Urticaria
    • Vasculitis
  • Gastrointestinal
    • Abdominal pain
    • Nausea, vomiting
  • Hematologic
    • Anemia
    • Leukopenia
    • Thrombocytopenia
  • Musculoskeletal
    • Arthralgia
    • Arthritis
    • Myositis
  • Neuropsychiatric
    • Cranial neuropathies
    • Organic brain syndrome
    • Peripheral neuropathies
    • Psychosis
    • Seizures
    • Transverse myelitis
  • Pulmonary
    • Pleurisy
    • Pulmonary hypertension
    • Pulmonary parenchyma
  • Renal
    • Casts
    • Hematuria
    • Nephrotic syndrome
    • Proteinuria
  • Reticuloendothelial
    • Hepatomegaly
    • Lymphadenopathy
    • Splenomegaly
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

01 Aug 2016
Etoricoxib exhibits a central mode of action and enhances pain and function in patients with painful knew osteoarthritis (OA), as presented in a randomised, double-blind, placebo-controlled, two-way crossover, four-week treatment study.
Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.