systemic%20lupus%20erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.

Introduction

  • Predominantly diagnosed in females of childbearing age
    • Rarely diagnosed before 8 years old
  • Clinical presentation varies in different patients & the disease activity varies over time in a single patient
    • Majority of patients have arthralgia of the hand

Definition

  • Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens & immune-complex formation
    • SLE can be suspected when ≥2 organ systems are involved

Signs and Symptoms

Clinical features of systemic lupus erythematosus (SLE)

  • Cardiac
    • Endocarditis
    • Myocarditis
    • Pericarditis
  • Constitutional
    • Fatigue
    • Fever
    • Weight loss
  • Dermatological
    • Alopecia
    • Butterfly rash
    • Mucous membrane lesion
    • Photosensitivity
    • Purpura
    • Raynaud’s phenomenon
    • Urticaria
    • Vasculitis
  • Gastrointestinal
    • Abdominal pain
    • Nausea, vomiting
  • Hematologic
    • Anemia
    • Leukopenia
    • Thrombocytopenia
  • Musculoskeletal
    • Arthralgia
    • Arthritis
    • Myositis
  • Neuropsychiatric
    • Cranial neuropathies
    • Organic brain syndrome
    • Peripheral neuropathies
    • Psychosis
    • Seizures
    • Transverse myelitis
  • Pulmonary
    • Pleurisy
    • Pulmonary hypertension
    • Pulmonary parenchyma
  • Renal
    • Casts
    • Hematuria
    • Nephrotic syndrome
    • Proteinuria
  • Reticuloendothelial
    • Hepatomegaly
    • Lymphadenopathy
    • Splenomegaly
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
15 Sep 2018
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
13 Sep 2018
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
Tristan Manalac, 2 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.