systemic%20lupus%20erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be diagnosed with a single organ involvement such as lupus nephritis.
It is predominantly diagnosed in females of childbearing age.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.

Systemic Lupus Erythematosus References

  1. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999 Sep;42(9):1785-1796. doi: 10.1002/1529-0131(199909)42:9<1785::AID-ANR1>3.0.CO;2-#. PMID: 10513791
  2. Bertsias G, Loannidis JPA, Boletis J, et al. EULAR recommendations for the management of systemic lupus erythematosus: report of a task force of the EULAR standing committee for international clinical studies including therapeutics. Ann Rheum Dis. 2008 Feb;67(2):195-205. doi: 10.1136/ard.2007.070367. PMID: 17504841
  3. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. doi: 10.1136/ard.2010.13047. PMID: 20724309
  4. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Aug 19, 2010. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. http://ard.bmj.com/content/69/12/2074.full.pdf+html. PMID: 20724309
  5. Cervera R, Font J. Therapeutic perspectives in systemic lupus erythematosus. Current Rheumatol Rev. 2005 Jan;1(1):45-47
  6. Gill JM, Quisel AM, Rocca PV, et al. Diagnosis of systemic lupus erythematosus. Am Fam Physician. 2003 Dec;68(11):2179-2186. http://www.aafp.org/afp/2003/1201/p2179.pdf. PMID: 14677663
  7. Kumar A. Indian guidelines on the management of SLE. J Indian Rheumatol Assoc. 2002;10:80-96
  8. Petri M. Treatment of systemic lupus erythematosus: an update. Am Fam Physician. 1998 Jun;57(11):2753-2760. http://www.aafp.org/afp/1998/0601/p2753.html. PMID: 9636338
  9. Knott HM, Martinez JD. Innovative management of lupus erythematosus. Dermatol Clin. 2010 Jul;28(3):489-499. doi: 10.1016/j.det.2010.03.007. PMID: 20510759
  10. Hahn BH, McMahon MA, Wilkinson A, et al; American College of Rheumatology. American College of Rheumatology guidelines for screening, case definition, treatment and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012 Jun;64(6):797-808. doi: 10.1002/acr.21664. PMID: 22556106
  11. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012 Aug;64(8):2677-2686. doi: 10.1002/art.34473. PMID: 22553077
  12. Yong PFK, D’Cruz DP. Mycophenolate mofetil in the treatment of lupus nephritis. Biologics. 2008 Jun;2(2):297-310. PMID: 19707362
  13. Gripenberg-Gahmberg M. Systemic lupus erythematosus (SLE). EBM Guidelines. Evidence-Based Medicine. Helsinki, Finland: Wiley Interscience, John Wiley & Sons; 2006 May
  14. Tassiulas IO, Boumpas DT. Clinical features and treatment of systemic lupus erythematosus. In: Firestein GS, Budd RC, Harris ED Jr, et al. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia: Elsevier W.B. Saunders; 2008
  15. Schmidt MJ, Adams SL. Tendinopathy and bursitis. In: Marx JA, ed-in-chief. Rosen’s emergency medicine: concepts and clinical practice. 7th ed. Philadelphia, PA: Mosby, an imprint of Elsevier; 2009.
  16. Klein-Gitelman MS. Systemic lupus erythematosus. In: Kliegman RM, Behrman RE, Jenson HB, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, PA: Saunders, Elsevier; 2007.
  17. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  18. Hsieh C. Belimumab for systemic lupus erythematosus. American College of Rheumatology website. http://www.rheumatology.org. Accessed 29 Aug 2013.
  19. Bartels CM. Systemic lupus erythematosus. eMedicine. summary/summary.aspx?doc_id= 11044&nbr=005823&string=. 2007
  20. Bartels CM. Systemic lupus erythematosus. eMedicine. http://www.emedicine.com. 2007. Accessed 22 Sep 2008.
  21. Klein-Gitelman MS. Systemic lupus erythematosus. eMedicine. http://www.emedicine.com. 2006.
  22. Klein-Gitelman MS. Systemic lupus erythematosus. eMedicine. seborrheic+AND+dermatitis. 2006
  23. Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 Sep;78(9):1151-1159. doi: 10.1136/annrheumdis-2018-214819. Accessed 10 May 2020. PMID: 31383717
  24. Fanouriakis A, Kostopoulou M, Alunno A, et al. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis. 2019 Jun;78(6):736-745. doi: 10.1136/annrheumdis-2019-215089. Accessed 06 May 2020. PMID: 30926722
  25. Gordon C, Amissah-Arthur MB, Gayed M, et al; British Society for Rheumatology Standards, Audit and Guidelines Working Group. The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults. Rheumatology (Oxford). 2018 Jan 1;57(1):e1-e45. doi: 10.1093/rheumatology/kex286. PMID: 29029350
  26. Castrejon I, Rua-Figueroa I, Rosario MP, et al. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: a systematic literature review. Reumatol Clin. Sep-Oct 2014;10(5):309-320. doi: 10.1016/j.reuma.2014.01.012. Accessed 13 Jun 2020. PMID: 25022441
  27. Chessa E, Piga M, Floris A, et al. Use of Physician Global Assessment (PGA) in systemic lupus erythematosus: a systematic review of its psychometric properties. medRxiv website. https://www.medrxiv.org. 17 Apr 2020. Accessed 13 Jun 2020.
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Jun 2018
Men with systemic lupus erythematosus (SLE) are more likely to develop coronary artery calcifications (CAC) than age- and sex-matched controls, a recent study has shown. Such risk among patients with SLE is associated with older age, increasing chronic damage and cumulative dose of corticosteroids.