systemic%20lupus%20erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.
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  2. Bertsias G, Loannidis JPA, Boletis J, et al. EULAR recommendations for the management of systemic lupus erythematosus: report of a task force of the EULAR standing committee for international clinical studies including therapeutics. Ann Rheum Dis. 2008 Feb;67(2):195-205. http://ard.bmj.com/content/67/2/195.full.pdf+html. PMID: 17504841
  3. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. doi: 10.1136/ard.2010.13047. PMID: 20724309
  4. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Aug 19, 2010. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. http://ard.bmj.com/content/69/12/2074.full.pdf+html. PMID: 20724309
  5. Cervera R, Font J. Therapeutic perspectives in systemic lupus erythematosus. Current Rheumatol Rev. 2005 Jan;1(1):45-47
  6. Gill JM, Quisel AM, Rocca PV, et al. Diagnosis of systemic lupus erythematosus. Am Fam Physician. 2003 Dec;68(11):2179-2186. http://www.aafp.org/afp/2003/1201/p2179.pdf. PMID: 14677663
  7. Kumar A. Indian guidelines on the management of SLE. J Indian Rheumatol Assoc. 2002;10:80-96
  8. Petri M. Treatment of systemic lupus erythematosus: an update. Am Fam Physician. 1998 Jun;57(11):2753-2760. http://www.aafp.org/afp/1998/0601/p2753.html. PMID: 9636338
  9. Knott HM, Martinez JD. Innovative management of lupus erythematosus. Dermatol Clin. 2010 Jul;28(3):489-499. doi: 10.1016/j.det.2010.03.007. PMID: 20510759
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