Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be diagnosed with a single organ involvement such as lupus nephritis.
It is predominantly diagnosed in females of childbearing age.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.
Rheumatic diseases, particularly rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, psoriatic arthritis, and osteoarthritis, appear to pose an increased risk of dementia, a study has reported.
Atacicept demonstrates efficacy in systemic lupus erythematosus (SLE), reducing disease activity and severe flare while having an acceptable safety profile, especially in patients with high disease activity and serologically active disease, according to results from the phase IIb, multicentre ADDRESS II trial.
Patients with systemic lupus erythematosus (SLE) are prone to have cognitive impairment (CI), and the Montreal Cognitive Assessment (MoCA) appears to be a useful tool for detecting CI in SLE, according to a recent study. In addition, CI is less likely to occur in patients with more years of education.
Patients with systemic lupus erythematosus (SLE), compared to those without, have an increased risk of mortality after the first month following an ischaemic stroke, a recent study has found. In addition, functionality becomes poorer at 3 months.
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.