Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.
Roshini Claire Anthony speaks with Dr Annie Law, a consultant at the Department of Rheumatology & Immunology, Singapore General Hospital, on how primary care physicians can help in the management of systemic lupus erythematosus (SLE).
Short- and long-term renal outcomes improve with early renin–angiotensin–aldosterone system (RAAS) blockade with renin–angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study.
Ofatumumab appears to be effective and well-tolerated in the treatment of patients with long-standing systemic lupus erythematosus, offering an alternative to the B cell–depleting agent rituximab, according to a study.
It appears that the Patient Reported Outcomes Measurement Information System Global Health Short Form (PROMIS10), which requires less than 2 minutes to complete, is useable, reliable and can efficiently screen for impaired physical function, emotional distress and pain in outpatients with systemic lupus erythematosus (SLE), reports a study.
Belimumab appears to provide long-term benefits in patients with active systemic lupus erythematosus (SLE), reducing disease activity and prednisone usage while having low accrual of organ damage, according to data from the continuation phase of the multicentre BLISS-76 study from US.
Both the dose and the intensity of longitudinal use of glucocorticoid (GC) are associated with the risk of adverse events (AE) among a nationwide Asian systemic lupus erythematosus (SLE) cohort, according to a recent study.
Treatment with belimumab in Asian patients with systemic lupus erythematosus (SLE) appears to yield significant improvements in disease activity, with a corticosteroid-sparing effect and no new safety signals emerging, according to the results of a phase III trial.
Rheumatic diseases, particularly rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, psoriatic arthritis, and osteoarthritis, appear to pose an increased risk of dementia, a study has reported.
Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.