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SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.

Differential Diagnosis

  • Antiphospholipid antibody syndrome
  • Drug-induced lupus
  • Early rheumatoid arthritis
  • Fibromyalgia w/ positive antinuclear antibody (ANA)
  • Idiopathic athrombocytopenic purpura
  • Scleroderma
  • Sjogren’s syndrome
  • Systemic sclerosis
  • Undifferentiated connective tissue disease
  • Vasculitis
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Audrey Abella, 14 Sep 2017
The interleukin-6 receptor-alpha inhibitor tocilizumab alone or in combination with methotrexate demonstrated clinical benefit after 2 years of treatment in methotrexate-naïve patients with early rheumatoid arthritis (RA), according to the FUNCTION* trial.