systemic%20lupus%20erythematosus%20(pediatric)
SYSTEMIC LUPUS ERYTHEMATOSUS (PEDIATRIC)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.

Systemic%20lupus%20erythematosus%20(pediatric) Signs and Symptoms

Introduction

  • Predominantly diagnosed in females of childbearing age
    • Rarely diagnosed before 8 years old

Definition

  • Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens & immune-complex formation
    • Systemic lupus erythematosus (SLE) can be suspected when ≥2 organ systems are involved

Signs and Symptoms

  • Clinical presentation varies in different patients & the disease activity varies over time in a single patient
    • Majority of patients have arthralgia of the hand
    • Most frequent manifestations in children include fever, rash, alopecia, arthritis & renal involvement
    • Compared w/ adults, children have a higher incidence of malar rash, anemia, leukopenia, neurologic & renal involvement


Clinical features of SLE

  • Cardiac
    • Endocarditis
    • Myocarditis
    • Pericarditis
  • Constitutional
    • Fatigue
    • Fever
    • Wt loss
  • Dermatological
    • Alopecia
    • Butterfly rash
    • Mucous membrane lesion
    • Photosensitivity
    • Purpura
    • Raynaud’s phenomenon
    • Urticaria
    • Vasculitis
  • Gastrointestinal
    • Abdominal pain
    • Nausea, vomiting (N/V)
  • Hematologic
    • Anemia
    • Leukopenia
    • Thrombocytopenia
  • Musculoskeletal
    • Arthralgia
    • Arthritis
    • Myositis
  • Neuropsychiatric
    • Cranial neuropathies
    • Organic brain syndrome
    • Peripheral neuropathies
    • Psychosis
    • Seizures
    • Transverse myelitis 
  • Pulmonary
    • Pleurisy
    • Pulmonary hypertension
    • Pulmonary parenchyma
  • Renal
    • Casts
    • Hematuria
    • Nephrotic syndrome
    • Proteinuria
  • Reticuloendothelial
    • Hepatomegaly
    • Lymphadenopathy
    • Splenomegaly
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 2 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Christina Lau, 6 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.