systemic%20lupus%20erythematosus%20(pediatric)
SYSTEMIC LUPUS ERYTHEMATOSUS (PEDIATRIC)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
It can be suspected when ≥2 organ systems are involved.
It is predominantly diagnosed in females of childbearing age, rarely diagnosed before 8 years old.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Majority of patients have arthralgia of the hand.
  1. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999 Sep;42(9):1785-1796. http://onlinelibrary.wiley.com/doi/10.1002/1529-0131(199909)42:9%3C1785::AID-ANR1%3E3.0.CO;2-%23/pdf. PMID: 10513791
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  3. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Aug 19, 2010. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. http://ard.bmj.com/content/69/12/2074.full.pdf+html. PMID: 20724309
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  5. Gill JM, Quisel AM, Rocca PV, et al. Diagnosis of systemic lupus erythematosus. Am Fam Physician. 2003 Dec;68(11):2179-2186. http://www.aafp.org/afp/2003/1201/p2179.pdf. PMID: 14677663
  6. Kumar A. Indian guidelines on the management of SLE. J Indian Rheumatol Assoc. 2002;10:80-96
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  8. Hahn BH, McMahon MA, Wilkinson A, et al; American College of Rheumatology. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012 Jun;64(6):797-808. doi: 10.1002/acr.21664. PMID: 22556106
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  14. Bartels CM. Systemic lupus erythematosus. eMedicine. http://www.emedicine.com/med/topic2228.htm. 2007. Accessed 22 Sep 2008
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