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SYSTEMIC LUPUS ERYTHEMATOSUS (PEDIATRIC)
Treatment Guideline Chart
Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Childhood-onset SLE has a greater disease severity and earlier disease damage than in adults with SLE.

Systemic Lupus Erythematosus (Pediatric) References

  1. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999 Sep;42(9):1785-1796. doi: 10.1002/1529-0131(199909)42:9<1785::AID-ANR1>3.0.CO;2-#. PMID: 10513791
  2. Bertsias G, Loannidis JPA, Boletis J, et al. EULAR recommendations for the management of systemic lupus erythematosus: report of a task force of the EULAR standing committee for international clinical studies including therapeutics. Ann Rheum Dis. 2008 Feb;67(2):195-205. doi: 10.1136/ard.2007.070367. PMID: 17504841
  3. Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010 Dec;69(12):2074-2082. http://ard.bmj.com/content/69/12/2074.full.pdf+html. PMID: 20724309
  4. Cervera R, Font J. Therapeutic perspectives in systemic lupus erythematosus. Current Rheumatol Rev. 2005 Jan;1(1):45-47
  5. Gill JM, Quisel AM, Rocca PV, et al. Diagnosis of systemic lupus erythematosus. Am Fam Physician. 2003 Dec;68(11):2179-2186. http://www.aafp.org/afp/2003/1201/p2179.pdf. PMID: 14677663
  6. Kumar A. Indian guidelines on the management of SLE. J Indian Rheumatol Assoc. 2002;10:80-96
  7. Petri M. Treatment of systemic lupus erythematosus: an update. Am Fam Physician. 1998 Jun;57(11):2753-2760. http://www.aafp.org/afp/1998/0601/p2753.html. PMID: 9636338
  8. Hahn BH, McMahon MA, Wilkinson A, et al; American College of Rheumatology. American College of Rheumatology guidelines for screening, case definition, treatment and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012 Jun;64(6):797-808. doi: 10.1002/acr.21664. PMID: 22556106
  9. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012 Aug;64(8):2677-2686. doi: 10.1002/art.34473. PMID: 22553077
  10. Gripenberg-Gahmberg M. Systemic lupus erythematosus (SLE). EBM Guidelines. Evidence-Based Medicine. Helsinki, Finland: Wiley Interscience, John Wiley & Sons; 2006 May
  11. Klein-Gitelman MS. Systemic lupus erythematosus. In: Kliegman RM, Behrman RE, Jenson HB, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, PA: Saunders, Elsevier; 2007.
  12. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  13. Hsieh C. Belimumab for systemic lupus erythematosus. American College of Rheumatology. http://www.rheumatology.org. Accessed 29 Aug 2013.
  14. Bartels CM. Systemic lupus erythematosus. eMedicine. http://www.emedicine.com. 2007. Accessed 22 Sep 2008.
  15. Klein-Gitelman MS. Systemic lupus erythematosus. eMedicine. http://www.emedicine.com. 2006.
  16. van Vollenhoven RF, Mosca M, Bertsias G, et al. Treat-to-target in systemic lupus erythematosus: recommendations from an international task force. Ann Rheum Dis. 2014 Jun;73(6):958-967. http://ard.bmj.com/content/early/2014/04/16/annrheumdis-2013-205139.full.pdf. Accessed 02 Oct 2015. PMID: 24739325
  17. Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 Sep;78(9):1151-1159. doi: 10.1136/annrheumdis-2018-214819. Accessed 10 May 2020. PMID: 31383717
  18. Fanouriakis A, Kostopoulou M, Alunno A, et al. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis. 2019 Jun;78(6):736-745. doi: 10.1136/annrheumdis-2019-215089. Accessed 06 May 2020. PMID: 30926722
  19. Castrejon I, Rua-Figueroa I, Rosario MP, et al. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: a systematic literature review. Reumatol Clin. Sep-Oct 2014;10(5):309-320. doi: 10.1016/j.reuma.2014.01.012. Accessed 13 Jun 2020. PMID: 25022441
  20. Chessa E, Piga M, Floris A, et al. Use of Physician Global Assessment (PGA) in systemic lupus erythematosus: a systematic review of its psychometric properties. medRxiv. https://www.medrxiv.org. 17 Apr 2020. Accessed 13 Jun 2020.
  21. Klein-Gitelman M. Systemic lupus erythematosus (SLE) in children: treatment, complications, and prognosis. UpToDate. https://www.uptodate.com. 07 Jun 2019.
  22. Levy D. Childhood-onset systemic lupus erythematosus (SLE): clinical manifestations and diagnosis. UpToDate. https://www.uptodate.com. 29 Jun 2020.
  23. Pinheiro SVB, Dias RF, Fabiano RCG, et al. Pediatric lupus nephritis. J Bras Nefrol. Apr-Jun 2019;41(2):252-265. doi: 10.1590/2175-8239-JBN-2018-0097. PMID: 30465590
  24. Thakral A, Klein-Gitelman M. An update on treatment and management of pediatric systemic lupus erythematosus. Rheumatol Ther. 2016 Dec;3(2):209-219. doi: 10.1007/s40744-016-0044-0. PMID: 27747587
  25. Groot N, de Graeff N, Avcin T, et al. European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative. Ann Rheum Dis. 2017 Nov;76(11):1788-1796. doi: 10.1136/annrheumdis-2016-210960. PMID: 28630236
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