Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory,
autoimmune disorder characterized by formation of autoantibodies
directed against self-antigens and immune-complex formation.
Clinical presentation varies in different patients and the disease
activity varies over time in a single patient. Childhood-onset SLE has a greater disease severity and earlier disease damage than in adults with SLE.
Antiviral treatment with tenofovir alafenamide fumarate (TAF) during pregnancy in highly viraemic mothers effectively prevents mother-to-child transmission (MTCT) of hepatitis B virus (HBV) with no safety concerns, according to two studies presented during the AASLD 2020 Liver Meeting.