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SYSTEMIC LUPUS ERYTHEMATOSUS (PEDIATRIC)
Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against self-antigens and immune-complex formation.
Clinical presentation varies in different patients and the disease activity varies over time in a single patient. Childhood-onset SLE has a greater disease severity and earlier disease damage than in adults with SLE.

Differential Diagnosis

  • Antiphospholipid antibody syndrome
  • Castleman disease
  • Drug-induced lupus
  • Early rheumatoid arthritis
  • Fibromyalgia with positive antinuclear antibody (ANA)
  • Idiopathic thrombocytopenic purpura
  • Kikuchi-Fujimoto disease
  • Malignancies, eg acute lymphoblastic leukemia
  • Other vasculitides
  • Scleroderma
  • Sjogren’s syndrome
  • Systemic sclerosis
  • Undifferentiated connective tissue disease
  • Viral infections, eg parvovirus and herpesviruses
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