Schizophrenia is a devastating mental illness characterized by symptoms eg hallucinations, disorganized thinking, loss of goal-directed behaviors and deterioration in social role functioning.
Positive or psychotic symptoms are delusions, hallucinations, and distorted perceptions.
Negative symptoms include flat or blunted emotions, lack of motivation or energy, lack of pleasure or interest in things, and limited speech.
Disorganized symptoms are confused thinking, disorganized speech and behavior.
Cognitive symptoms include impairment in attention verbal fluency memory, and executive functioning.
Relapse in schizophrenia appears to contribute to increased treatment resistance, with a recent study showing that response to antipsychotic medication is reduced or delayed in patients who relapse after effective treatment of the first episode.
Children born to parents with schizophrenia are at increased risk of developing a variety of neurological disorders, as well as visual and hearing disorders, at an early age, a study has found. The same is true for those born to parents with a major depression.
Antipsychotic drug treatment appears to be less effective in patients with higher polygenic risk score (PRS) for schizophrenia, suggests a study. PRS burden appears to be useful as a prognostic biomarker.
Major depressive disorder (MDD) commonly occurs in schizophrenic patients and is associated with several factors including paranoid delusions and avolition, a study reports. Moreover, although antidepressants produce improvements in symptom level, many patients remain depressed despite treatment.
A 12-week circuit-training exercise intervention is a safe and feasible adjunct treatment in patients with first-episode psychosis, with potential benefits to certain domains of cognitive functioning especially in females, a study has shown.
Children born to parents with schizophrenia or major depression are at greater risk of developing a variety of neurological, visual and hearing disorders at an early age compared with offspring of parents from the general population, according to a study.
Individuals with incident schizotypal disorder and substance use disorders, particularly opioid, amphetamine, or cannabis use disorders, have an increased risk of developing schizophrenia, according to a recent study from Denmark.
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.