Schizophrenia is a devastating mental illness characterized by symptoms eg hallucinations, disorganized thinking, loss of goal-directed behaviors and deterioration in social role functioning.
Positive or psychotic symptoms are delusions, hallucinations, and distorted perceptions.
Negative symptoms include flat or blunted emotions, lack of motivation or energy, lack of pleasure or interest in things, and limited speech.
Disorganized symptoms are confused thinking, disorganized speech and behavior.
Cognitive symptoms include impairment in attention verbal fluency memory, and executive functioning.
Use of long-acting injectable risperidone appears to produce rapid and progressive reduction in symptoms of schizophrenia patients with acute exacerbation, eliminating the need for oral risperidone supplementation or loading doses, according to a study.
Treatment with the combination of olanzapine and samidorphan results in significantly less weight gain and smaller increases in waist circumference compared with olanzapine alone, results of a phase III study have shown. In addition, the combination treatment is well tolerated, and its antipsychotic efficacy is comparable to that of olanzapine monotherapy.
Treatment with the long-acting injectable antipsychotic aripiprazole appears to reduce hospitalization in recent-onset schizophrenia, which can lead to a lower socioeconomic healthcare burden, according to a study.
In the initial period of schizophrenia, consistent adherence to long-acting antipsychotic medication may enhance the effects of cognitive remediation (CR) and produce significant improvements in core cognitive deficits and work/school performance, according to the results of a trial.
In the treatment of schizophrenia, patients on typical antipsychotics have better memory than those taking clozapine or risperidone, and patients on clozapine have better language function compared with those on risperidone, as shown in a study.
Patients with schizophrenia, regardless of medication, exhibit pervasive deficits in cognitive function, including the domains of reinforcement learning, processing speed, cognitive control, working memory, verbal learning, and relational encoding and retrieval, a study has shown.
Chronic schizophrenia patients receiving long‐acting injectable antipsychotics (LAIAs) have more favourable outcomes than those receiving oral antipsychotics in the maintenance setting, with LAIAs tied to a lower risk of disease relapse and a reduction in psychiatric service utilization, as shown in a study.