An initial strategy of 1-year romosozumab followed by alendronate is superior over alendronate alone in reducing new vertebral fractures in postmenopausal women with osteoporosis at high risk for fracture, according to the ARCH* study.
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
Atacicept demonstrates efficacy in systemic lupus erythematosus (SLE), reducing disease activity and severe flare while having an acceptable safety profile, especially in patients with high disease activity and serologically active disease, according to results from the phase IIb, multicentre ADDRESS II trial.
Researchers from Japan have suggested several factors, namely younger age at DMARD* therapy initiation and low serum C-reactive protein (CRP) levels, as factors that may predict successful down-titration of biologic DMARDs in patients with rheumatoid arthritis.
Patients with rheumatoid arthritis (RA) who are overweight or obese have a higher degree of histologically-proven follicular synovitis. Furthermore, body mass index (BMI) appears to impact response to treatment in these patients, according to a study presented at the annual meeting of the ACR/ARHP* held in San Diego, California, US.
Tocilizumab may improve skin score and forced vital capacity stabilization in patients with systemic sclerosis, while potentially increasing the risk of serious infections, according to the open-label data of the faSScinate* trial.
Women who temporarily or permanently stop taking bisphosphonates (drug holiday) for an extended period of time may have an increased risk of hip fractures, findings from a recent population-based study revealed.
Patients with systemic lupus erythematosus (SLE) are prone to have cognitive impairment (CI), and the Montreal Cognitive Assessment (MoCA) appears to be a useful tool for detecting CI in SLE, according to a recent study. In addition, CI is less likely to occur in patients with more years of education.
Dr. Priscilla Wong, Dr. Lydia Tam, Prof. LS Tam, 20171110000000
This case report highlights that psoriatic arthritis is a heterogenous disease affecting multiple disease domains, and effective treatment requires thorough assessment of each of these different domains.
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.