In the treatment of select patients with rheumatoid arthritis (RA), otilimab is neither better than placebo nor noninferior to sarilumab in terms of the proportion of patients achieving an American College of Rheumatology ≥20 percent response (ACR20), according to the results of the phase III ContRAst 3 study.
Combination treatment with glucocorticoid (GC) plus hydroxychloroquine appears to yield more favourable outcomes than GC alone in the treatment of systemic lupus erythematosus (SLE) rash, while having a good safety profile, according to a study.
Following the switch from combination therapy to monotherapy, rheumatoid arthritis (RA) patients with overall lower disease activity (LDA) have higher odds of achieving and remaining in Simplified Disease Activity Index (SDAI) remission/LDA, suggests a study.
New drug applications approved by US FDA as of 16-31 August 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Use of ixekizumab (IXE) for 3 years in patients with axial spondyloarthritis (axSpA) is safe, which is consistent with the previously established long-term safety profile, reports a study. Treatment with IXE results in sustained improvement of disease activity through 156 weeks.
In a pooled, post hoc analysis of the AURA-LV and AURORA 1 studies, lupus nephritis (LN) patients with moderate-to-high baseline levels of proteinuria (UPCR* ≥2 to ≥3 mg/mg) who were receiving add-on voclosporin achieved higher renal response rates and earlier UPCR reductions vs those who were only treated with the control regimen.