Adding fenofibrate to allopurinol or febuxostat reduces uric acid levels in patients with gout without showing any significant change in renal or hepatic functions, a recent study has shown. This suggests that cotreatment of fenofibrate with xanthine oxidase inhibitors is a reasonable option for treating gout in patients who have high triglyceride levels.
Psoriatic arthritis (PsA) at time of diagnosis worsens health-related quality of life (HRQOL) in comparison to the reference population, a Dutch study has found. Tender joints, enthesitis at clinical examination and back pain as indicators of pain affect HRQOL.
Women with silicone breast implants are at heightened risk of subsequently developing an autoimmune/rheumatic disorder, specifically sarcoidosis, systemic sclerosis and Sjögren’s syndrome, according to a study.
Flares are common in rheumatoid arthritis (RA) patients with low disease activity (LDA), according to a study. Flares also correlate with worse disease activity, quality of life and radiographic progression.
Low-dose methotrexate, which is approved for the treatment of rheumatoid arthritis (RA) and other autoimmune disorders, has shown unexpectedly disappointing results in preventing cardiovascular (CV) events among patients with a prior myocardial infarction (MI) or multivessel coronary disease, according to CIRT*, potentially ruling out what could be an affordable option for treating inflammation related to atherosclerosis.
Ixekizumab is safe and effective in the treatment of patients with active radiographic axial spondyloarthritis and previously inadequate response or intolerance to tumour necrosis factor inhibitors, producing rapid and significant improvements in the signs and symptoms, according to the 16-week results of the phase III COAST-W trial.
In utero exposure to hydroxychloroquine (HCQ) appears to reduce the risk of developing cutaneous neonatal lupus erythematosus, as shown in a multicentre case-control study. Moreover, there is a trend toward delayed rash onset in HCQ-exposed infants with cNL.
There appears to be inconsistent evidence regarding the use of an arm support or an alternative mouse at the workplace and its effect of the incidence of neck or shoulder musculoskeletal disorders among office workers, according to the results of a review and meta-analysis.