The administration of intra-articular hypertonic dextrose prolotherapy (DPT) injections led to improvements in function, pain, and quality of life (QoL) in patients with knee osteoarthritis (OA) compared with normal saline (NS) injections, a Hong Kong study has shown.
Engaging in long-term strenuous physical activities* was not associated with radiographic knee osteoarthritis (OA) in individuals at an increased risk for but without radiographic evidence of the disease, a new study has shown.
Internal fixation surgery did not significantly improve functional outcomes in patients with closed, displaced humeral shaft fractures compared with nonoperative functional bracing, the FISH* trial has shown.
Women with rheumatoid arthritis (RA) have a reduced risk of breast cancer; similarly, women with breast cancer have a reduced risk of RA, reveals a Swedish study. Moreover, adjuvant antihormonal therapy for breast cancer prevention does not appear to increase the risk of RA.
Individually calibrated biomechanical footwear therapy may be effective in reducing knee pain and physical function in individuals with symptomatic knee osteoarthritis (OA), according to the results of the BIOTOK* trial.
The sGC* stimulator riociguat did not offer substantial benefit for patients with early, diffuse cutaneous systemic sclerosis (SSc) who are at high risk for skin fibrosis progression; however, other potential efficacy signals should not be discounted, the phase IIb RISE-SSc** trial has shown.
Use of the nerve growth factor (NGF) inhibitor tanezumab led to significant improvements in pain and physical function in patients with moderate-to-severe osteoarthritis (OA) of the hip and knee who have intolerance or insufficient response to standard analgesics*, a phase III study has shown.
Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.