The osteoporosis medications teriparatide, romosozumab, raloxifene and denosumab all confer significant benefits for reducing vertebral and hip fractures and inducing changes in bone mineral density at the femoral neck as compared with placebo, according to the results of a network meta-analysis.
In patients with active psoriatic arthritis (PsA), treatment with secukinumab at 300 and 150 mg with or without loading regimen inhibits radiographic progression, the rates of which remaining low over 52 weeks of treatment, while showing consistent clinical efficacy and a favourable safety profile, according to the 52-week data from phase III FUTURE 5 trial.
The Janus kinase inhibitor tofacitinib remained effective and safe even after discontinuing the csDMARD* methotrexate in patients with moderate-to-severe rheumatoid arthritis (RA) who achieved low disease activity (LDA) with a combination of the two drugs, the ORAL Shift** trial suggests, highlighting the feasibility of methotrexate withdrawal in this setting.
The addition of the monoclonal immunoglobulin G1 antibody bimekizumab to the anti-TNF* certolizumab pegol (CZP) led to a reduction in disease activity in rheumatoid arthritis (RA) patients with insufficient response to CZP, a study shows.
New drug application approved by US FDA as of 16 - 31 October 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
The efficacy and safety of the biosimilar IBI303 mirrored that of the monoclonal anti-TNFα* antibody adalimumab, thus providing a new and affordable treatment alternative for individuals with ankylosing spondylitis, according to a Chinese study.
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
New drug applications approved by US FDA as of 16 - 31 August 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Use of the Janus kinase (JAK) inhibitor upadacitinib in the treatment of rheumatoid arthritis (RA) yields significant improvements in signs, symptoms and physical function, in addition to inhibiting radiographic progression as compared with placebo, according to the results of the phase III SELECT-COMPARE trial.
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.