The addition of the monoclonal immunoglobulin G1 antibody bimekizumab to the anti-TNF* certolizumab pegol (CZP) led to a reduction in disease activity in rheumatoid arthritis (RA) patients with insufficient response to CZP, a study shows.
New drug application approved by US FDA as of 16 - 31 October 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
The efficacy and safety of the biosimilar IBI303 mirrored that of the monoclonal anti-TNFα* antibody adalimumab, thus providing a new and affordable treatment alternative for individuals with ankylosing spondylitis, according to a Chinese study.
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
New drug applications approved by US FDA as of 16 - 31 August 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Use of the Janus kinase (JAK) inhibitor upadacitinib in the treatment of rheumatoid arthritis (RA) yields significant improvements in signs, symptoms and physical function, in addition to inhibiting radiographic progression as compared with placebo, according to the results of the phase III SELECT-COMPARE trial.
Belimumab for systemic lupus erythematosus (SLE) has demonstrated a stable safety profile over 8 years of follow-up, with no new safety signal and minimal organ damage progression, according to data from an extension study involving non-American patients who completed the phase III BLISS*-52 or BLISS-76 trials.
Uric acid-lowering therapy for gout also confers benefits for hyperlipidaemia, with febuxostat delivering greater reductions in cholesterol and triglyceride concentrations in the blood as compared with allopurinol and benzbromarone, according to a recent study.
Adults with moderate-to-severe rheumatoid arthritis (RA) with inadequate response or intolerance to biologic disease-modifying antirheumatic drugs (bDMARDs) may benefit from treatment with the selective Janus kinase (JAK)-1 inhibitor filgotinib, the phase III FINCH 2* trial shows.
Progression of skin fibrosis* within 1 year is associated with long-term deterioration in lung function and worse survival in individuals with diffuse cutaneous systemic sclerosis (dcSSc), according to data from the EUSTAR** cohort.
The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.