Low-dose oral colchicine appears to be effective at controlling knee osteoarthritis (KOA) progression and severity by reducing inflammation and high bone turnover markers, according to a recent Singapore study. On the other hand, it does not improve KOA symptoms in the short term.
Using the JAK* inhibitor tofacitinib as induction therapy for Crohn’s disease (CD) can promote disease remission in certain patients selected based on baseline endoscopic evidence of inflammation, according to a post hoc analysis presented at the recent Crohn's & Colitis Congress (CCC) 2018, Las Vegas, Nevada, US.
Local infiltration analgesia (LIA) using liposomal bupivacaine led to favourable pain management outcomes by improving post-surgical pain and reducing opioid consumption following total knee arthroplasty (TKA), the PILLAR* study shows.
Treatment with belimumab in Asian patients with systemic lupus erythematosus (SLE) appears to yield significant improvements in disease activity, with a corticosteroid-sparing effect and no new safety signals emerging, according to the results of a phase III trial.
CNTO6785, a fully human monoclonal antibody (mAb) that binds to human interleukin (IL) 17A, is well tolerated (RA) but fails to show efficacy in active rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX) therapy, according to a study.
There appears to be a substantial number of patients developing chronic joint pain at a median of 20 months following infection with chikungunya virus, as shown in a study involving a large Latin American cohort.
Rheumatic diseases, particularly rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, psoriatic arthritis, and osteoarthritis, appear to pose an increased risk of dementia, a study has reported.
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.
Tofacitinib, a first-in-class Janus kinase (JAK) inhibitor, shows promise as an oral treatment with quick onset of action and sustained efficacy in patients with psoriatic arthritis (PsA) who do not respond adequately to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).
Dr. Priscilla Wong, Dr. Lydia Tam, Prof. LS Tam,
10 Nov 2017
This case report highlights that psoriatic arthritis is a heterogenous disease affecting multiple disease domains, and effective treatment requires thorough assessment of each of these different domains.