Patients with the radiographic axial spondyloarthritis subtype, known as ankylosing spondylitis, are more likely to be positive for human leukocyte antigen-B27, hypertensive, and have uveitis and poorer spinal mobility, whereas those with the nonradiographic subtype are more prone to experience poorer well-being and quality of life, according to data from a multiethnic Asian population in Singapore.
Early neuromuscular blockade (NMB) with concomitant heavy sedation in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) did not result in a significant mortality difference vs usual care, the ROSE* trial has shown.
Treatment with the tyrosine kinase inhibitor (TKI) nintedanib reduces pulmonary function decline in patients with systemic sclerosis–associated interstitial lung disease (SSc-ILD), according to the phase III SENSCIS* trial which is touted as the largest randomized controlled trial in SSc-ILD thus far.
Intake of sugar-sweetened beverage and fruit juice appears to increase the risk of developing gout, and this adverse association does not extend to fruit consumption, according to the results of a meta-analysis.
In pregnant women with well-controlled rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), tumour necrosis factor inhibitor (TNFi) may be discontinued before gestational week 20 without the risk of disease worsening, as shown in a study.
Biweekly treatment with pegloticase yields favourable effects on systolic and diastolic blood pressure as well as mean arterial pressure in gout patients who maintain a persistently low serum urate, and these effects are independent of changes in renal function, according to a posthoc analysis of two trials.
Tofacitinib yields clinical and radiographic improvements in rheumatoid arthritis (RA) patients with inadequate response to methotrexate, and such improvements are sustained for up to 24 months without new safety signals, according to the results of the phase III ORAL* Scan trial.
In rheumatoid arthritis (RA) patients in remission, increasing the dose interval of tocilizumab injection from the standard 162 mg once weekly to twice weekly may do more harm than good. Specifically, such a strategy is associated with a lower chance of remission maintenance as well as a lack of improvement in tolerability, as shown in a recent trial.
A new osteoporosis guideline by the Endocrine Society puts a premium on women at high risk of fractures, particularly those who have had a recent fracture after menopause, and outlines the latest pharmacologic options for specific patient groups.
Physicians are likely to underestimate the severity of psoriatic arthritis (PsA) in patients who are older, show higher fatigue levels, complain of greater pain or have poorer mental health, according to a Singapore study. In contrast, overestimation of disease severity by physicians tends to occur in the presence of higher swollen joint counts.
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.