Treatment with canakinumab yields a rapid, substantial improvement in disease activity in children with systemic juvenile idiopathic arthritis (sJIA), according to long-term extension data from two phase III pivotal trials. Furthermore, response is sustained for up to 5 years, allowing dose reduction or even discontinuation of glucocorticoids without raising new safety concerns.
A 1-year course of induction therapy with a tumour necrosis factor inhibitor plus methotrexate appears to be beneficial to patients with early inflammatory arthritis, producing responses that are sustained long after cessation of therapy, according to the results of the DINORA* trial.
Teriparatide appears to produce significant reductions in the incidence of fractures in the period beyond 6 months after treatment initiation, with the benefit consistently observed across important patient subgroups, according to data from four real-world studies.
Febuxostat does not appear to be more cardiotoxic than allopurinol in the treatment of elderly gout patients with or without cardiovascular comorbidities, according to a recent study. Neither drug is associated with elevated risks of cardiovascular events and all-cause mortality.
Acoustic radiation force impulse sonoelastography is a promising noninvasive technique for tissue rigidity evaluation, detecting pathological changes in the salivary glands and facilitating diagnosis of Sjögren's syndrome, according to a study.
The selective xanthine oxidoreductase (XOR) inhibitor topiroxostat reduced the serum uric acid (SUA) level of patients with hyperuricaemia and early diabetic nephropathy (DN) with microalbuminuria, preventing the decline in estimated glomerular filtration rate (eGFR), according to the UPWARD* study.
Rheumatoid arthritis (RA) disease control appears to be better with continued 4-mg baricitinib treatment than with a 2-mg dose step-down approach, according to substudy data from the ongoing phase III RA-BEYOND extension trial.
A novel light therapy which combines infrared, red and violet light emitted through LEDs* appears safe and improves the conditions of finger ulcers in patients with systemic sclerosis (SSc), a pilot study shows.
Continued therapy with the tumour necrosis factor inhibitor adalimumab appears to yield a higher rate of maintenance of remission in patients with nonradiographic axial spondyloarthritis (axSpa) as opposed to treatment withdrawal, according to the results of the ABILITY-3 study.
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
Smoking appears to increase the risk of abdominal aortic aneurysm, particularly among current smokers, reports a recent meta-analysis. The risk appears to taper with a lower number of cigarette sticks smoked per day.