Flare rates appear to be similar after tapering of a tumour necrosis factor (TNF) inhibitor or a conventional synthetic disease-modifying antirheumatic drug (csDMARD) up to 9 months in patients with rheumatoid arthritis (RA) who have achieved disease control, with a nonsignificant 10-percent difference in flare rates after 1 year in favour of csDMARDs, according to data from the TARA* study.
Treatment with epidural steroid injections with dexamethasone results in a limited side effect on glucose and cortisol homeostasis among Asian patients presenting with lower back pain or sciatica, according to a Singapore study. An optimal dose of steroid must then be used in selected patients to maximize benefits while reducing the side effects.
New drug applications approved by US FDA as of 01 - 15 April 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Use of oral contraceptives (OC) confers some protection against bone loss in patients with anorexia nervosa (AN), a study has found. Areal bone mineral density preservation improves with longer durations of OC use and shorter delays between disease onset and OC initiation, and appears to be most pronounced in patients more severe forms of AN.
Greater parity, early age at menarche, or oral contraceptive use may increase a woman’s risk of undergoing total knee replacement (TKR) for severe knee osteoarthritis (OA), according to findings from the Singapore Chinese Health Study (SCHS).
Treatment with tofacitinib yields significant improvements in signs and symptoms of rheumatoid arthritis (RA) in patients from the Asia Pacific, according to data from a posthoc analysis. The drug has a safety profile consistent with global tofacitinib studies, although infections occur more frequently in Asians.
A recent systematic review and meta-analysis has shown that the effects of spinal manipulative therapy (SMT) for chronic low back pain are comparable to those of recommended therapies. However, SMT appears to be better than sham therapy, nonrecommended interventions or when added as an adjuvant therapy for short-term improvement in function.
An assessment system consisting of a wearable device and a smartphone app promises reliable recording of pain in individuals with chronic pain, including fibromyalgia. The resulting data accurately reflect pain status and help alleviate pain, according to the results of a pilot study.
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.
Rupatadine at either 10 or 20 mg delivers superior improvements in nasal and ocular symptoms of seasonal allergic rhinitis compared with placebo, with both doses well tolerated by adult and adolescent patients, according to the results of a phase III trial.