Using diclofenac in combination with TPC (thiamine, pyridoxine and cyanocobalamin) offers superior analgesic effect than diclofenac monotherapy in the management of acute lower back pain, according to a systematic review and meta-analysis.
Gout entails an increased risk of advanced chronic kidney disease (CKD), and the risk is strongest for the outcome of end-stage kidney disease (ESKD) but extended to other surrogate measures of CKD progression, a study has found.
Partial knee replacement surgery provides similar clinical outcomes as total knee replacement in patients with late-stage osteoarthritis (OA), although the former proves more cost-effective according to the results of the TOPKAT* trial.
The previous use of multiple disease-modifying antirheumatic drugs (DMARDs) and disease duration appear to affect treatment outcomes in rheumatoid arthritis patients initiating adalimumab therapy, according to a posthoc analysis of two randomized controlled trials.
Ethnic variations are present in some systemic sclerosis (SSc) disease manifestations, and although this does not lead to significant differences in short-term survival, it may influence long-term survival, suggests a recent study.
Vasodilator therapy and low-dose acetylsalicylic acid appear to protect against the incidence of distinct manifestations of myocardial disease in patients with systemic sclerosis (SSc), a recent study has found.
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.