Exposure to psychotropic drugs and proton pump inhibitors (PPIs) contributes to an increase risk of clinical and nonvertebral fractures in postmenopausal women with severe osteoporosis, according to a study. Furthermore, teriparatide confers superior benefits for reducing the risk of fractures compared with risedronate, irrespective of such an exposure.
A programmed treatment strategy of refining infliximab (IFX) doses based on baseline serum tumour necrosis factor α falls flat in sustaining remission rate in rheumatoid arthritis patients after 1 year of IFX discontinuation, according to the results of the multicentre randomized RRRR* trial.
Treatment with lovastatin appears to have neither anti-inflammatory nor clinical effects on mild rheumatoid arthritis (RA) disease activity, although it produces a modest reduction in C-reactive protein (CRP) in patients not using biologics, according to the results of a phase II study.
There appears to be a borderline positive association between high-sensitivity C-reactive protein (hs-CRP) and long-term risk of coronary heart disease (CHD) among middle-aged and elderly individuals with hyperuricaemia, a study reports.
Monotherapy with tocilizumab (TCZ) shows good tolerability profile and results in remission in most patients with polymyalgia rheumatica (PMR) despite the absence of glucocorticoids, according to the 2-year results of a single-centre, open‐label pilot study.
Among patients with axial spondyloarthritis (axSpA) in Singapore, work productivity is lower in the presence of active disease, reduced physical function and poorer quality of life, as reported in a Singapore study.
Radiofrequency ablation and neuromodulation modalities for knee osteoarthritis (OA) potentially improve pain, functionality and disease-specific quality of life for up to 3–12 months with minimal localized complications, according to the results of a systematic review.
Patients with systemic sclerosis appear to have a higher prevalence of lower urinary tract syndrome (LUTS) compared with healthy individuals, with LUTS associated with sarcopaenia, bone damage and calcinosis, suggesting a possible interplay, according to a recent study.
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.