Bisphosphonates bear an increased hazard of developing atypical femur fracture, which rapidly decreases following treatment discontinuation, according to a study. This risk is more pronounced in Asians than in whites.
Long-term use of low-dose glucocorticoids results in a dose-dependent increase in the risk of serious infection in patients with rheumatoid arthritis (RA) on stable disease-modifying antirheumatic drug (DMARD) regimen, with small but significant risk even at doses of ≤5 mg/day, a study has shown.
Pregabalin, used either alone or in combination with milnacipran, is effective in the treatment of patients with fibromyalgia, and combined therapy does not confer added benefits compared with monotherapy, according to a study.
Optical spectral transmission (OST) values are higher among patients with rheumatoid arthritis than controls, results of a study have shown. OST is also associated with clinical, ultrasound, and laboratory disease activity markers.
Self-reported flares are common and generally managed by analgesics in rheumatoid arthritis (RA), according to a study. In addition, they are substantiated higher activity measures, independently associated with pain and patient-reported swollen joints, and linked to treatment intensification.
Advanced chronic kidney disease (CKD) associated with lupus nephritis (LN) does not necessarily lead to a need for dialysis, suggests a study, which shows majority of its patients (62 percent) not progressing over 10 year of follow-up on average.
Hand osteoarthritis (OA) shows an association with physical, but not mental, health-related quality of life (HRQOL) in the general population and hospital patients, a study has found. A further decline in physical HRQOL is seen in hospital care and with concurrent knee OA.
Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.