Women with rheumatoid arthritis (RA) appear to have low utilization of medications safe to take during pregnancy, commonly discontinuing their medications in the first trimester, a recent study has found.
Among older patients with chronic low back pain and depression who are treated with venlafaxine, exposure to opioids is associated with reduced likelihood of achieving early pain response but not that of attaining the combined pain/depression outcome, a study has shown.
Treatment with pamidronate appears to improve clinical and radiological disease activity in children categorized with extended chronic nonbacterial osteomyelitis (CNO), particularly after 1 year of treatment, a study has shown. However, some children present with active disease after 2 years of pamidronate use.
The oral, selective Janus kinase 1 inhibitor filgotinib confers a significant improvement in health-related quality of life in patients with active psoriatic arthritis (PsA), according to data from the phase II EQUATOR trial.
Exposure to psychotropic drugs and proton pump inhibitors (PPIs) contributes to an increase risk of clinical and nonvertebral fractures in postmenopausal women with severe osteoporosis, according to a study. Furthermore, teriparatide confers superior benefits for reducing the risk of fractures compared with risedronate, irrespective of such an exposure.
A programmed treatment strategy of refining infliximab (IFX) doses based on baseline serum tumour necrosis factor α falls flat in sustaining remission rate in rheumatoid arthritis patients after 1 year of IFX discontinuation, according to the results of the multicentre randomized RRRR* trial.
Treatment with lovastatin appears to have neither anti-inflammatory nor clinical effects on mild rheumatoid arthritis (RA) disease activity, although it produces a modest reduction in C-reactive protein (CRP) in patients not using biologics, according to the results of a phase II study.
There appears to be a borderline positive association between high-sensitivity C-reactive protein (hs-CRP) and long-term risk of coronary heart disease (CHD) among middle-aged and elderly individuals with hyperuricaemia, a study reports.
The outcomes after arthroscopic partial meniscectomy (APM) do not appear to be superior to placebo surgery in patients without knee osteoarthritis but with symptoms of a degenerative medial meniscus tear, according to 2-year data from a recent study.