Treatment with anakinra appears beneficial to children with secondary haemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS), especially when administered early in the disease course and to those who have an underlying rheumatic disease, as shown in a study.
Use of ustekinumab in the treatment of systemic lupus erythematosus leads to significant improvements in many of the efficacy indices evaluated, with lower risk of flares and sustained response rates, when compared with placebo, according to 1-year data from a phase II trial.
Components of the renin-angiotensin system (RAS), such as renin, angiotensin-converting enzyme (ACE), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), are more elevated in the synovial fluid of patients with rheumatoid arthritis (RA) than with osteoarthritis (OA), a recent study has shown.
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.