Current smoking reduces the response of patients with early rheumatoid arthritis (RA) to methotrexate (MTX) in a dose-responsive manner, regardless of concomitant prednisone use, a recent study has found.
Among systemic lupus erythematosus patients, SARS-CoV-2-specific immune responses after BNT162b2 vaccination seem to be impaired in the presence of poor baseline humoral immune status, low naïve B cell frequencies, and mycophenolate mofetil (MMF) and methotrexate (MTX) use, according to a study.
Patients with systemic lupus erythematosus (SLE) show progressive reduction in the thickness of peripapillary retinal nerve fibre layer, suggestive of early neurodegeneration, a recent study has found.
Use of tofacitinib for rheumatoid arthritis (RA) may lead to reactivation of hepatitis B virus (HBV), especially among hepatitis B surface antigen-positive (HBsAg+) and HBsAg-negative/hepatitis B core antibody-positive (HBsAg–/HBcAb+) patients, according to a study from Taiwan.
Being inactive (zero 10-min bouts/week in moderate-to-vigorous physical activity [MVPA]) is associated with a higher risk of developing functional limitation in adults with knee osteoarthritis (OA), regardless of sedentary category, a study has found.
Treatment with tocilizumab, an interleukin (IL)-6 receptor antagonist, is effective for corticosteroid sparing in patients with giant cell arteritis (GCA), suggests a study. However, tocilizumab allows for a prolonged remission in fewer than half of the patients following treatment discontinuation.