Use of antidepressants in older women has been linked to cortical bone and physical function deterioration, effects that are specific to selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs), a study has found.
Patients with colchicine-resistant familial Mediterranean fever benefit from long-term treatment with canakinumab, preventing flares and controlling disease activity without increasing adverse events, according to the results of a phase III study.
Several serum biomarkers of disease activity have been recognized in giant cell arteritis (GCA) and eosinophilic granulomatosis with polyangiitis (EGPA), according to a study. Moreover, differences in biomarker levels between diseases are more evident than those related to disease activity.
Treatment with canakinumab produces improvements in systemic juvenile idiopathic arthritis (sJIA), which occur shortly after initiation and last up to 6 months, according to the results of an open‐label, active treatment extension study.
Higher serum uric acid (UA) levels appear to be protective against vertebral fracture among elderly men, whereas excessive reduction of serum UA using urate-lowering medications confers a risk increase, a study has shown.
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.