Gut inflammation, as indicated by elevated faecal calprotectin levels, may be a marker of more severe disease in patients with axial spondyloarthritis, according to data from the SPARTAKUS cohort. Specifically, increased calprotectin levels are associated with worse disease activity and physical function.
An association exists between poor/intermediate preconceptional cardiovascular (CV) health and pregnancy outcomes of preterm birth and small for gestational age (SGA) infants among women with systemic lupus erythematosus (SLE), suggests a recent study.
Inhibition of interleukin-1 with lutikizumab falls short in the treatment of patients with knee osteoarthritis, with the results of a phase II study showing that the drug yields limited reductions in pain without any improvement in synovitis.
Community-dwelling elderly men with hyperglycaemia are at increased risk of developing fractures, with the risk of major osteoporotic fractures pronounced in those with prediabetic glycaemic status, a study suggests.
Individuals with imaging-defined or biopsy-proven nonalcoholic fatty liver disease are likely to have a self‐reported history of osteoporotic fractures but not a low bone mineral density, according to a meta-analysis.
Both high and low levels of hydroxychloroquine (HCQ) exposure in pregnant women with systemic lupus erythematosus (SLE) are associated with preterm birth and disease activity, reports a recent study, suggesting that further researcher is needed to understand HQC disposition throughout pregnancy and to clarify the relationship between drug levels and outcomes.
Rates of total hip arthroplasty (THA) increased twofold over the years in older patients with ankylosing spondylitis (AS), outpacing that in the general population, according to a study. There has also been a substantial increase in rates of total knee arthroplasty (TKA) in older patients with AS.
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.