Women are more likely to have a lower rate of response to treatment and of disease remission in axial spondyloarthritis (axSpA) treated with antitumour necrosis factor (anti-TNF)-α medications, according to a recent study.
The use of opioid analgesics among patients with ankylosing spondylitis (AS) appears to be associated with subjective measures (depression, Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Bath Ankylosing Spondylitis Functional Index [BASFI]) than objective measures (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]), according to a study.
Women with rheumatoid arthritis (RA) appear to have better functional status prior to menopause, with a recent study reporting that menopause is associated with a worsening progression of functional decline in RA.
Short-term treatment with methotrexate at >0.5 defined daily dose (8.75 mg/week) may help reduce the risk of ischaemic stroke in rheumatoid arthritis (RA) patients, while hydroxychloroquine and sulfasalazine have neutral effects, a retrospective study has found.
There appears to be a significant proportion of patients with psoriatic arthritis (PsA) in Hong Kong who have asymptomatic hyperuricaemia, which is closely associated with body mass index but not with severity of skin disease, joint involvement or renal function, according to a study.
Exposure to ozone (O3) in the second year of life and cigarette smoke (intrauterine and after birth) and maternal occupational exposure may increase the risk of juvenile idiopathic arthritis (JIA), suggests a recent study.
Infants with in utero exposure to maternal rheumatoid arthritis (RA) are at an increased risk of developing thyroid disease, epilepsy and RA in childhood and adolescence, a study from Denmark suggests.
Baricitinib has shown consistent safety and tolerability up to 128 weeks, with no unexpected late signals, according to the results of a phase IIb study in rheumatoid arthritis (RA). In addition, clinical improvements during the 24-week blinded period persist during the open-label extension (OLE).
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.
Tofacitinib, a first-in-class Janus kinase (JAK) inhibitor, shows promise as an oral treatment with quick onset of action and sustained efficacy in patients with psoriatic arthritis (PsA) who do not respond adequately to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).
Dr. Priscilla Wong, Dr. Lydia Tam, Prof. LS Tam,
10 Nov 2017
This case report highlights that psoriatic arthritis is a heterogenous disease affecting multiple disease domains, and effective treatment requires thorough assessment of each of these different domains.