Long-term use of low-dose glucocorticoids results in a dose-dependent increase in the risk of serious infection in patients with rheumatoid arthritis (RA) on stable disease-modifying antirheumatic drug (DMARD) regimen, with small but significant risk even at doses of ≤5 mg/day, a study has shown.
Pregabalin, used either alone or in combination with milnacipran, is effective in the treatment of patients with fibromyalgia, and combined therapy does not confer added benefits compared with monotherapy, according to a study.
Optical spectral transmission (OST) values are higher among patients with rheumatoid arthritis than controls, results of a study have shown. OST is also associated with clinical, ultrasound, and laboratory disease activity markers.
Self-reported flares are common and generally managed by analgesics in rheumatoid arthritis (RA), according to a study. In addition, they are substantiated higher activity measures, independently associated with pain and patient-reported swollen joints, and linked to treatment intensification.
Advanced chronic kidney disease (CKD) associated with lupus nephritis (LN) does not necessarily lead to a need for dialysis, suggests a study, which shows majority of its patients (62 percent) not progressing over 10 year of follow-up on average.
Hand osteoarthritis (OA) shows an association with physical, but not mental, health-related quality of life (HRQOL) in the general population and hospital patients, a study has found. A further decline in physical HRQOL is seen in hospital care and with concurrent knee OA.
Patients with knee osteoarthritis may experience better pain relief with celecoxib than with diclofenac sodium, in addition to having lower levels of inflammatory markers and complication risk, a study has found.
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.