Infants born to mothers with rheumatoid arthritis treated with tumour necrosis factor inhibitors (TNFIs) during pregnancy do not have a heightened risk of developing serious infections, a study reports.
Treatment with rituximab (RTX) is well tolerated and leads to stability or improvement in pulmonary function or severity of interstitial lung disease (ILD) on computed tomography (CT) in most patients, a recent study has shown.
Age, weight, oral corticosteroid use and strenuous exercise at age 18 years appear to be useful in predicting the 5-year risk of height loss of at least 1 inch in postmenopausal women, according to a study.
Pneumococcal responses with methotrexate (MTX) exposure show that antirheumatic drugs may limit humoral responses to vaccination, but such treatment remains safe and must not prevent immunization against vaccine-preventable disease, according to the results of a systematic review and meta-analysis.
Men with systemic lupus erythematosus (SLE) are more likely to develop coronary artery calcifications (CAC) than age- and sex-matched controls, a recent study has shown. Such risk among patients with SLE is associated with older age, increasing chronic damage and cumulative dose of corticosteroids.
The risk of developing acute anterior uveitis or inflammatory bowel disease, but not psoriasis, appears to increase with disease duration in axial spondyloarthritis (AxSpA), and this risk is associated with higher cumulative exposure to inflammation, as reported in a study.
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.
Rheumatoid arthritis (RA) patients receiving long-term treatment with mavrilimumab demonstrate continued response and a positive safety profile, with no increased incidence of treatment-emergent adverse events (AEs), according to an analysis of two phase IIb studies (1071 and 1107) and one open-label extension study. Additionally, there are similar safety data from both phase IIb qualifying studies.
Patients with inflammatory bowel disease (IBD) do not have an increased risk of overall fractures, although steroid use poses an elevated risk of fractures at the spine, according to the results of a systematic review and meta-analysis.
Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.