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Top Medical News
The development of scleroderma renal crisis (SRC), a severe life-threatening complication in patients with systemic sclerosis (SSc), is rare, but its highest risk is associated with the detection of anti-RNA polymerase antibodies (RNAP) and proteinuria, suggests a recent study.
Experts worldwide support the updated recommendations for the treatment of systemic sclerosis (SSC) as shown by their high agreement, reports a study. Differences in agreement are partially due to geographical area and treatment availability.
A recent US-based study showed that the targeted synthetic (ts)DMARD* tofacitinib may not have a higher risk of serious infection compared with all biologic DMARDs (bDMARDs).
A higher prednisolone dose results in a marked reduction in the relapse rate among patients with Takayasu arteritis (TA), reveals a recent study. Moreover, lower-dose prednisolone monotherapy appears to be a disadvantageous strategy for remission induction in TA despite low disease activity.
Timely therapeutic strategies appear to effectively manage gastrointestinal (GI) risk in ankylosing spondylitis (AS) patients undergoing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), as shown in a recent study.
Blocking the toll-like receptor (TLR) 4 pathway with NI-0101, a first-in-class humanized monoclonal antibody, has failed to improve disease parameters in rheumatoid arthritis in a phase II trial.
Patients with axial spondyloarthropathy (axSpA) are at greater risk of multimorbidity, which also happens to exacerbate the disease, reports a study.
Special Reports
With the objective of establishing a Malaysian consensus on the use of topical NSAIDs in the management of musculoskeletal pain, this meeting brought together experts from various backgrounds, ie, rheumatology, pharmacy, orthopaedics and general medicine. At the meeting, Dr Mary Suma Cardosa delivered a talk on the pathophysiology and effective management of pain, while the lecture by Dr Yeap Swan Sim focused on the management of musculoskeletal and soft-tissue pain. This article presents excerpts from the expert meeting and features the consensus statements agreed during the meeting.
At the International Osteoporosis Foundation Regionals – 6th Asia-Pacific Osteoporosis Meeting in Singapore, Professor Olivier Bruyère shared about the algorithm for the management of knee OA by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). MIMS Doctor also spoke to Professor Jean-Yves Reginster, president of ESCEO about this algorithm and the role of SYSADOAs in the control of pain and prevention of disease progression.
Conference Reports
Privacy and transparency are among the core points to consider when utilizing big data in rheumatic and musculoskeletal disorders (RMDs), according to the first EULAR-endorsed recommendations for use of big datasets in research.
A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.
Patients with painful hand osteoarthritis can finally get relief from pain with low-dose prednisolone, suggests a study presented at EULAR 2019.
Occupational exposure to inorganic dust, particularly asbestos, silica, and coal, was associated with an increased risk of developing gout, according to a study presented at EULAR 2019.
Being overweight may have an impact on disease severity in psoriatic arthritis, according to a study presented at EULAR 2019.
The selective Janus kinase 1 inhibitor upadacitinib demonstrated sustained efficacy and safety beyond 12 weeks in patients with moderate-to-severe rheumatoid arthritis (RA) who had inadequate response or were refractory to disease-modifying antirheumatic drugs (DMARDs), according to the interim results of the ongoing extension phases of SELECT-NEXT* and SELECT-BEYOND** presented at EULAR 2019.
Both inflammatory bowel disease (IBD) and type 1 diabetes (T1D) are highly prevalent among patients who eventually develop rheumatoid arthritis (RA), indicating that these two conditions are potential risk factors for RA, according to a study presented at EULAR 2019.
