There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Oncologists refer patients for genomic profiling to guide diagnosis, treatment options after standard therapy, or to determine eligibility for basket studies in cases of refractory and rare tumours. Next generation sequencing (NGS) is becoming to be the gateway to precision medicine in oncology. Elvira Manzano from MIMS Oncology spoke with Dr Federico Rojo from the Fundacion Jimenez Diaz University Hospital in Madrid, Spain on the impact of NGS on precision cancer therapy during a genomic oncology symposium in Singapore.
Transdermal administration of emedastine difumarate provides effective control of symptoms of seasonal allergic rhinitis, with the effects sustained throughout the day and raising no safety signals of clinical concern, according to the results of a phase III trial.
Prednisolone appears to be more effective than itraconazole in terms of inducing response in patients with acute-stage allergic bronchopulmonary aspergillosis, a study reports. On the other hand, itraconazole demonstrates better safety profile, being associated with fewer side effects.
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.
Combining the monoclonal antibody targeting PD-L1 atezolizumab and the antiangiogenic biologic bevacizumab with a chemotherapy of carboplatin + paclitaxel (CP) for treating non-squamous metastatic non-small-cell lung cancer (NSCLC) leads to significant improvement in progression-free survival (PFS) compared with bevacizumab + CP as first-line treatment, according to the IMpower150* trial presented at the ESMO Immuno Oncology Congress 2017.
Respiratory infections potentially play a role in precipitating acute myocardial infarction (AMI), with a recent study showing that the incidence of admissions for AMI is high during the week following laboratory confirmation of influenza infection.
Decreased serum vitamin D levels appear to confer an increased risk of asthma, bronchitis, wheeze and chest tightness, a study reports. Conversely, increased vitamin D levels are associated with higher levels of lung function.
Better clinical efficacy was observed among cancer patients with postoperative hospital-acquired pneumonia (HAP) who received prolonged infusion of the mixed preparation of the broad-spectrum β-lactamase inhibitor tazobactam and β-lactam antibiotic piperacillin (TZP) compared with those who received the traditional regimen, according to a study.
Infants with persistent rhinitis have a higher abundance of Actinobacteria, especially Corynebacterium spp., in their nasal microbiome compared with healthy controls, according to a Singapore-based study presented at the European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress 2016 held in Vienna, Austria.
“At present, there is a limited development of new antibiotics. There is also a fast development of resistance to antibiotics. There are pathogens no longer susceptible to all antibiotics, and many pathogens are no longer susceptible to most antibiotics,” said Dr. Andre Villanueva, chief of party of the USAID’s Innovations and Multisectoral Partnerships to Achieve Control of TB (IMPACT) Project at the recent Annual Convention of the Philippine Pharmacists’ Association in Davao City.