Adding the anti-GM-CSF* receptor-α monoclonal antibody mavrilimumab to standard care (SC) improved clinical outcomes in patients with severe coronavirus disease 2019 (COVID-19) pneumonia and systemic hyperinflammation who were not under mechanical ventilation (MV), an Italian study has shown.
As Hong Kong battles with a third wave of the coronavirus disease 2019 (COVID-19) outbreak, researchers from the University of Hong Kong (HKU) and several institutions in the US have identified 13 drugs at clinical stage or approved by the US FDA that may effectively inhibit replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Amidst the global race for a vaccine against COVID-19, the Ad5*-vectored COVID-19 (Ad5-nCoV) vaccine gets a boost with the release of encouraging data from the phase II trial, which provide further evidence supporting the safety and immunogenicity of this vaccine.
Two doses of mRNA-1273, a novel lipid nanoparticle-encapsulated, nucleoside-modified mRNA-based vaccine, induced binding and neutralizing antibody responses against SARS-CoV-2 in healthy adults, according to an interim analysis of the mRNA-1273* trial.
Surgical masks are not equivalent to N95 respirators for reducing risk of infection and should not be regarded as interchangeable when N95 respirators are in shortage, especially in the setting of COVID-19 inpatient care.
Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.