New drug applications approved by US FDA as of 1 - 15 July 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Over three-quarter of Singaporean patients with obstructive sleep apnoea (OSA) who were adherent and took on continuous positive airway pressure (CPAP) therapy after a 1-month CPAP trial period continued to be adherent to the therapy at 1 year, indicating that initial receptibility to CPAP is predictive of long-term adherence to the therapy, a local study finds.
Respiratory infections, particularly influenza, may increase the risk of treatment failure in children with asthma who present to emergency departments (EDs) with exacerbations, a secondary analysis of the DOORWAY* study revealed.
Combining a long-acting beta-agonist (LABA) with an inhaled corticosteroid (ICS) did not lead to a higher risk of serious asthma-related events compared with ICS alone, according to a combined analysis of four large FDA-mandated postmarketing safety trials.
Matching targeted therapy to genetic alterations in the tumour improved response rate and long-term survival in patients with advanced cancer who underwent molecular profiling compared with patients who were unmatched to therapy, highlighting the role of molecular testing in precision medicine, the IMPACT* study shows.
Adding atezolizumab to a combination therapy of bevacizumab plus carboplatin and paclitaxel (CP) significantly improves progression-free survival (PFS) and overall survival (OS) in chemotherapy-naïve patients with metastatic nonsquamous non-small–cell lung cancer (NSCLC), irrespective of PD-L1 expression levels and EGFR or ALK alteration status, according to the IMpower150* trial presented at ASCO 2018.
A large number of patients who present at outpatient clinics with symptoms of acute respiratory infections (ARIs) during influenza seasons are prescribed antibiotics despite not needing them, a finding that highlights the overuse of antibiotics in ARIs, a recent study showed.
Experts from the Chinese University of Hong Kong (CUHK) have pioneered in the Asia Pacific region the use of electromagnetic navigation bronchoscopy (ENB) with hybrid operating room for removal of very small pulmonary lesions.
Fluticasone furoate is superior to mometasone nasal spray in improving several perceived sensory attributes of allergic rhinitis patients, based on a multicentre, randomised, crossover, prospective study.
In children and adolescents with cystic fibrosis (CF), synbiotic supplementation appears to be effective at reducing proinflammatory markers such as interleukin (IL)-6 and -8, and nitric oxide metabolites (NOx), a recent study has found.