Use of the blood infection biomarker procalcitonin as a guide to prescribing antibiotics led to lower antibiotic exposure and side effects, as well as a lower mortality rate in individuals with acute respiratory infections, based on findings of a meta-analysis.
Nearly half of food allergies observed in adults started appearing in adulthood, in contrast to common belief that most food allergies started in childhood, according to a US population-based survey presented at the ACAAI Annual Meeting 2017 in Boston, Massachusetts, US.
In paediatric patients with asthma, viral infection has minimal effect on measures of acute severity and clinical recovery, a study has found. Meanwhile, the risk of asthma relapse is elevated in the presence of atopy.
Inhaled bronchodilator therapy is central to symptom management in chronic obstructive pulmonary disease (COPD), and evidence points to an improvement in lung function and a reduction in symptoms when dual bronchodilator therapy is used over monotherapy. Tiotropium/olodaterol (Spiolto® Respimat®, Boehringer Inghelheim) is the latest dual bronchodilator therapy available in Malaysia. At its launch during the Malaysian Thoracic Society Annual Congress 2017, Professor Klaus F. Rabe spoke on this particular combination and the evidence for its use in COPD.
Age appears to be associated with specific asthma phenotypes, such that older patients are more likely to present with irreversible airway obstruction and severe asthma but less likely to have atopic and eosinophilic phenotypes compared with younger patients, according to a study.
The addition of a macrolide* to empirical β-lactam** therapy did not reduce length of hospitalization in children with pneumonia, a recent study found, raising questions on the routine use of macrolides in this setting.
Use of consolidative stereotactic ablative radiotherapy (SAbR) prior to maintenance chemotherapy improves progression-free survival (PFS) by more than 6 months in patients with non-small-cell lung cancer (NSCLC) who have limited metastases, a recent phase II study has shown. [ASTRO 2017, abstract LBA3; JAMA Oncol 2017, doi: 10.1001/jamaoncol.2017.3501]
Combination therapy with the CTLA-4 blocker, ipilimumab, and stereotactic ablative radiation therapy (SABR) is effective in cancers with metastatic lung and liver lesions, according to results presented at the 2017 Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Integrating robust smoking cessation programs with organized low-dose CT (LDCT) lung cancer screening may decrease mortality rates while being relatively cost-effective, according to a modelling study.
Middle East Respiratory Syndrome (MERS) patients have more severe illness and a higher mortality rate than non-MERS severe acute respiratory infection (SARI) patients, according to a study presented at the recent American Thoracic Society (ATS) International Conference 2016 held in San Francisco, California, US.
Fixed-dose combinations of long-acting β2-agonist (LABA) and muscarinic antagonist (LAMA) offered superior efficacy and comparable safety to LAMA or LABA/inhaled corticosteroid (ICS), the two most commonly prescribed first-line treatments for stable moderate-to-very-severe chronic obstructive pulmonary disease (COPD), according to a meta-analysis.
High free sugar intake during pregnancy was associated with a heightened risk of allergy and allergic asthma in the children, independent of their sugar intake during early childhood, according to the ALSPAC* study.