Use of mepolizumab in the treatment of severe eosinophilic asthma reduces exacerbation frequency and oral corticosteroid requirement, according to a study. Factors associated with better outcomes include nasal polyposis, lower body mass index and lower maintenance prednisolone requirement.
The risk of death in patients hospitalized for asthma exacerbation is associated with specific comorbidities, disease severity, and prescription patterns of short-acting β2-agonist, oral and inhaled corticosteroids, according to a study.
Adjuvanted FLU-v, a broad-spectrum influenza vaccine that induces antibodies and cell-mediate immunity, has demonstrated immunogenicity in a phase IIb trial, warranting phase III development to explore its safety and efficacy.
Bilevel positive airway pressure (BPAP) appears to be an effective therapeutic option in patients with moderate-to-severe obstructive sleep apnoea (OSA) who fail continuous positive airway pressure (CPAP) therapy due to low adherence, achieving adequate control of sleep-disordered breathing and its symptoms while being well tolerated, suggests a study.
Pneumonia caused by the coronavirus disease 2019 (COVID-19) in pregnant women shows similar clinical characteristics to that in nonpregnant adult patients with the same condition, according to a recent study.
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).
The gap in overall life expectancy between people with HIV (PWH) and those without HIV has narrowed over time, particularly among optimally treated PWH. However, PWH still have fewer comorbidity-free years than those without HIV, according to a study presented at CROI 2020.