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Original New Drug Application Approvals by US FDA (01 - 15 November 2018)

3 hours ago

New drug applications approved by US FDA as of 01 - 15 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Preventive hypertonic saline inhalation safe, effective for babies with cystic fibrosis

13 hours ago

Preventive inhalation of hypertonic saline (HS) safely and effectively improves lung clearance index (LCI) and leads to weight gain in infants with cystic fibrosis (CF), a recent trial has shown.

Pneumococcus can spread via hand-to-nose contact

Pearl Toh, 6 days ago

The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.

Treatment de-escalation in nosocomial pneumonia shortens hospital stay, lowers AKI risk

6 days ago

Among patients with culture-negative nosocomial pneumonia, de-escalation of antimethicillin-resistant Staphylococcus aureus therapy is associated with a shorter hospital stay and lower incidence of acute kidney injury (AKI), a study suggests. De-escalation does not alter 28-day mortality.

Human metapneumovirus, rather than RSV, impacts development of hypoxia in asthmatic children

07 Nov 2018

Outbreaks of human metapneumovirus (hMPV) instead of respiratory syncytial virus (RSV) appear to have a greater influence on the development of hypoxic respiratory illness in asthmatic children, a recent study has found.

Lactobacillus abundance tied to lower risk of childhood wheezing at age 2 years

07 Nov 2018

In infants with early-life acute respiratory infection (ARI) with respiratory syncytial virus (RSV), elevated nasopharyngeal Lactobacillus levels protect against wheezing illnesses at 2 years of age, a recent study has found.

CPAP for sleep apnoea does not enhance asthma control, but improves daytime sleepiness, QoL

05 Nov 2018

There appears to be a high prevalence of obstructive sleep apnoea syndrome (OSAS) among patients with asthma and snoring, reports a study. Continuous positive airway pressure (CPAP) treatment for 3 months does not improve asthma control but enhances daytime sleepiness, quality of life and vitality.

Antihistamine therapy for allergic rhinitis and urticaria: An Asia-Pacific perspective

01 Nov 2018

The prevalence of allergic diseases in the Asia-Pacific region is expected to rise over the next 20 years, driven by rapid economic development and urbanization. Allergic diseases have high socioeconomic impact by impairing productivity and quality of life, and the impact may be greater in Asia-Pacific than in Europe due to the presence and predominance of perennial allergens.

The role of intranasal corticosteroids in the management of allergic rhinitis

02 Aug 2018

At a dinner symposium at Le Méridien Kuala Lumpur, Professor Dato’ Prepageran Narayanan presented the data concerning allergic rhinitis (AR) in Malaysia, and he discussed the role of intranasal corticosteroids (INCSs) in managing AR.

Optimizing hypertension management in clinical practice with nebivolol

Prof. Giuseppe Mancia, Prof. Jong-Won Ha, Prof. Lin Jiunn-Lee, 11 Jul 2018

Hypertension guidelines diﬀer in their recommendation to use beta-blockers as ﬁrst-line agents. At a Menarini-sponsored symposium held during the Asian Paciﬁc Society of Cardiology Congress 2018 in Taipei, Taiwan, Professor Giuseppe Mancia from the University of Milano-Bicocca in Milan, Italy and Professor Jong-Won Ha from the Yonsei University College of Medicine in Seoul, Korea discussed the rationale behind these recommendations, and reviewed the role of beta-blockers in hypertension management, particularly the role of vasodilatory beta-blocker nebivolol (Nebilet^®, Menarini). Professor Lin Jiunn-Lee, APSC 2018 chairman and president of the Taiwan Society of Cardiology, chaired the symposium.

Home NIV and HST: Improving quality of care for patients with COPD and OSA

01 Jul 2018

Airway diseases – such as chronic obstructive pulmonary disease and obstructive sleep apnoea – have a significant impact on one’s health, quality of life and daily functioning. This article discusses how technological advancements in non-invasive ventilation and home sleep testing systems help to improve patient care and outcomes.

Contemporary management of paediatric respiratory diseases: A novel combo of secretolytic and bronchospasmolytic actions

22 Jan 2018

During the recent 2017 Engelhard-Delfi Conference, organized by Delfi Marketing Sdn Bhd, three renowned speakers shared their insights into paediatric respiratory medicine.

Advancing the treatment paradigm of idiopathic pulmonary fibrosis (IPF)

22 Jan 2018

Literature suggests that IPF is either the first or second most common interstitial lung disease (ILD) in pulmonology practice, with prevalence ranging from 17–86%. At the recent 3rd Respiratory Forum organized by Boehringer Ingelheim, Dr Felix Chua shared his insights into the importance of advancing the treatment paradigm of IPF, and the role of nintedanib (OFEV^®) in its management.

Dose and calcifications predict overall survival in NSCLC patients receiving RT

Dr. Joseph Delano Fule Robles, 19 Oct 2018

Investigators from the University of Manchester, Manchester, UK recently demonstrated a significant interaction between volume of identified calcifications and their mean radiotherapy (RT) dose in predicting survival in patients with non-small-cell lung cancer (NSCLC).

Age, lung V20 predict radiation pneumonitis

Jackey Suen, 16 Oct 2018

Age ≥60 years and ≥20 percent of normal lung volume receiving a radiation dose of ≥20 Gy (V20) are significant predictors of radiation pneumonitis (RP) in patients treated with intensity-modulated radiotherapy (IMRT) for lung cancer, a Chinese study has shown.

Tumour volume reduction during CRT linked to worse survival in locally advanced lung adenocarcinoma

Jackey Suen, 16 Oct 2018

Reduction in gross tumour volume (GTV) during concurrent chemoradiation therapy (CRT) may be linked to worse overall survival (OS) in patients with locally advanced lung adenocarcinoma, according to a recent study reported at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer (WCLC 2018).

Prognostic nutrition index strongly predicts survival in locally advanced NSCLC

Jackey Suen, 15 Oct 2018

Prognostic nutrition index (PNI) strongly predicts clinical outcomes in patients with locally advanced non-small-cell lung cancer (NSCLC), according to two studies presented at the International Association for the Study of Lung Cancer 19th World Conference on Lung Cancer (WCLC 2018).

Viral respiratory infection POCT could reduce unnecessary hospitalization, antibiotics

Roshini Claire Anthony, 09 Oct 2018

The implementation of point-of-care testing (POCT) for viral respiratory infections in emergency departments could reduce unnecessary hospitalizations and antibiotic treatment, according to a study from the UK.

Prophylactic cranial irradiation fails to improve overall survival in NSCLC

Dr. Joseph Delano Fule Robles, 08 Oct 2018

An updated 10-year analysis of the RTOG 0214 trial showed that the use of prophylactic cranial irradiation (PCI) improved disease-free survival (DFS) and reduced brain metastases, but failed to improve overall survival (OS) in patients with locally advanced non-small-cell lung carcinoma (LA-NSCLC).

Adding nintedanib to standard of care fails to improve PFS in pleural mesothelioma

Jackey Suen, 08 Oct 2018

Adding nintedanib to standard-of-care pemetrexed-cisplatin doublet chemotherapy does not improve progression-free survival (PFS) in patients with malignant pleural mesothelioma (MPM), the phase III LUME-Meso study has shown.

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