Renal%20cancer Signs and Symptoms

Signs and Symptoms

Introduction

Also known as renal adenocarcinoma or hypernephroma

Definition

Disease in which the cells in certain tissues of the kidney start to grow uncontrollably and form a tumor

Signs and Symptoms

Classic triad of symptoms:
- Flank pain
- Palpable abdominal mass
- Gross hematuria

Other Symptoms

Anemia
Fever
Hepatic dysfunction
Loss of appetite
Malaise
Night sweats
Weight loss
Varicocele

Risk Factors

Ages between 50-70 years old
Men are 2-3 times more likely to develop kidney cancer than women
Chronic hepatitis C infection
Chronic kidney disease or in long-term dialysis
Exposure to cadmium and asbestos
Family history of kidney cancer and hereditary diseases (eg von Hippel-Lindau, hereditary papillary renal carcinoma, Birt-Hogg-Dubé syndrome, tuberous sclerosis complex)
Africans have higher rates than Americans
High blood pressure
Obesity
Overuse of medications such as Aspirin, Paracetamol and Ibuprofen
Polycystic kidney disease
Tobacco smoking

Spotlight on multidrug-resistant gram-negative infections: New developments for an old problem

Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021

Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.